Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN7381 | Leojaponin |
| 1. Leojaponin is a prolyl oligopeptidase (POP) inhibitor. 2. Leojaponin exhibits significant cytoprotective activities against glutamate-induced toxicity at concentrations ranging from 0.1 microm to 10 microm. | |
| BCN7384 | Alternariol monomethyl ether |
| 1. Alternariol monomethyl ether,an Alternaria toxin, is a strong mutagen in Escherichia coli strain ND-160. 2. Alternariol monomethyl ether has genotoxic properties, it can cause oxidative DNA damage. 2. Alternariol monomethyl ether possesses cytotoxic and immunosuppressive properties. | |
| BCN7386 | Paspalinine |
| 1. Paspalinine can inhibit binding of [125I]charybdotoxin (ChTX) to maxi-K channels in bovine aortic smooth muscle sarcolemmal membranes. 2. Paspalinine shows tremorgenic action, which may be due in part to their inhibition of GABAA receptor function. | |
| BCN7387 | Dihydroxyaflavinine |
| 1. Dihydroxyaflavinine is a fungal toxin, it inhibits non-competitively GABAA receptor channel expressed in Xenopus oocytes. 2. Dihydroxyaflavinine shows oral toxicity to the fall armyworm (Spodoptera frugiperda) and corn earworm (Heliothis zea). | |
| BCN7389 | 4-Hydroxyalternariol 9-methyl ether |
| 1. 4-Hydroxyalternariol 9-methyl ether shows antibacterial activity against several tested bacterial pathogens with minimum inhibitory concentration values in the range of 86.7-364.7 uM. 2. 4-Hydroxyalternariol 9-methyl ether displays promising antioxidant effects. | |
| BCN7391 | Rosamultin |
| 1. Rosamultin has anti-human immunodeficiency virus (HIV) activity, it inhibited HIV-1 protease by 53% at a concentration of 100 microM. 2. Rosamultin has antioxidant properties, it may protect against bromobenzene-induced hepatotoxicity through, at least in part, enhanced activity of epoxide hydrolase. 3. Rosamultin may have antiinflammatory/antinociceptive action. | |
| BCN7392 | Altenuene |
| 1. Altenuene is a mycotoxin, it frequently occurs in food and feed items infested by fungi of the genus Alternaria. 2. Altenuene exhibits cytotoxic activity against lung cancer cell line A549, breast cancer cell line MDA-MB-231 and pancreatic cancer cell line PANC-1. 3. Altenuene demonstrates moderate activity against Staphylococcus aureus. | |
| BCN7393 | 1,3,9-Trimethyluric acid |
| 1. 1,3,9-Trimethyluric acid exhibits in vitro cytotoxic activity against breast cancer (MCF-7), human neuroblastoma (SHSY5Y), human non-small cell lung cancer (A549) and human liver cancer (HEPG2) with IC50 value in the range of 1-3 uM. 2. 1,3,9-Trimethyluric acid shows promising anti-inflammatory effects in LPS induced murine macrophage J774 in vitro models in the concentration range of 100-1000 nM. | |
