Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 265 - 272 of 9359 hot products
| Catalog No. | Product Name |
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| BCC1924 | SB 271046 hydrochloride |
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Selective, orally active 5-HT<sub>6</sub> antagonist (pK<sub>i</sub> values are 9.02-8.92, 6.55, 6.35, 6.27, 6.05, 5.95, 5.76, 5.73, 5.62, 5.55, 5.41, 5.39, 5.27 and < 4.99 at 5-HT<sub>6</sub>, 5-HT<sub>1D</sub>, 5-HT<sub>1A</sub>, D<sub>3</sub>, 5-HT<sub>1B</sub>, 5-HT<sub>1F</sub>, <span class='symbol'>α</span><sub>1B</sub>, 5-HT<sub>2C</sub>, 5-HT<sub>2A</sub>, D<sub>2</sub>, 5-HT<sub>2B</sub>, 5-HT<sub>7</sub>, 5-HT<sub>4</sub> and 5-HT<sub>1E</sub> respectively) and is > 200-fold selective over 55 other receptors, enzymes and ion channels. Increases extracellular glutamate and aspartate in the frontal cortex, and exhibits anticonvulsant activity (EC<sub>50</sub> = 0.16 <span class='symbol'>μ</span>M).
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| BCC1926 | SB-222200 |
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Potent and selective non-peptide NK3 receptor antagonist (Ki values are 4.4, > 100,000 and 250 nM for human NK3, NK1 and NK2 receptors respectively). Antihypertensive in vivo. Brain penetrant.
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| BCC1931 | SB-674042 |
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Potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM). Exhibits 100-fold selectivity for OX1 over OX2 receptors. Has no effect at serotonergic, dopaminergic, adrenergic or purinergic receptors. Inhibits orexin 1-induced Ca2+ mobilization in CHO-DG44 cells stably transfected with the OX1 receptor.
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| BCC1936 | SCH900776 S-isomer |
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SCH900776 S-isomer is the S-isomer of SCH900776. SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with IC50 of 3 nM.
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| BCC1938 | SD-208 |
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Potent, orally active ATP-competitive transforming growth factor-<span class='symbol'>β</span> receptor 1 (TGF-<span class='symbol'>β</span>RI) inhibitor (IC<sub>50</sub> = 49 nM). Displays > 100-fold and > 17-fold selectivity over TGF-<span class='symbol'>β</span>RII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity. Also promotes an antiglioma immune response. Ameliorates germinal matrix hemorrhage-induced neurological deficits in neonatal rats.
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| BCC1939 | SDZ 220-581 |
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Competitive NMDA receptor antagonist (pKi = 7.7). Centrally active following oral administration (ED50 < 3.2 mg/kg for protection against MES-induced seizures).
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| BCC1942 | Secalciferol |
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Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid
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| BCC1944 | Seocalcitol |
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Vitamin D receptor (VDR) agonist; analog of calcitriol. Exhibits anti-tumor and anti-proliferative activity with reduced hypercalcemic effects. 60 times more potent in inhibiting MCF-7 cell growth <em>in vitro</em>; also shown to induce autophagy in MCF-7 cells. Reverses the effects of parathyroid hormone-related protein (PTHrP).
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