Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 305 - 312 of 9359 hot products
| Catalog No. | Product Name |
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| BCC2096 | Gabexate mesylate |
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Serine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC<sub>50</sub> values are 9.4, 30, 41 and 110 <span class='symbol'>μ</span>M respectively). Antithrombotic <em>in vitro</em> and <em>in vivo</em>. Also inhibits LPS-induced TNF-<span class='symbol'>α</span> production, probably by inhibiting NF-<span class='symbol'>κ</span>B and AP-1 activation.
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| BCC2097 | Aspirin (Acetylsalicylic acid) |
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Inhibitor of cyclooxygenase (COX)-1. Blocks the production of prostaglandins and thromboxanes. Exhibits antiplatelet and antithrombotic activities. Displays anticancer effects in some solid tumors. One of the first described NSAID drugs.
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| BCC2098 | Disulfiram |
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Inhibitor of aldehyde dehydrogenase that displays antialcoholism activity. Shown to reversibly stimulate Ca<sup>2+</sup>-ATPase activity and inhibit V-ATPase (EC<sub>50</sub> = 26 <span class='symbol'>μ</span>M). Also inhibits expression of MMP-2 and MMP-9 and displays anti-invasive activity.
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| BCC2099 | Apoptosis Activator 2 |
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Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC<sub>50</sub> = 4 - 9 <span class='symbol'>μ</span>M for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC<sub>50</sub> > 40 <span class='symbol'>μ</span>M).
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| BCC2102 | LY2811376 |
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IC50: 239-249 nM (BACE1)
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| BCC2105 | LY3039478 |
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LY3039478 is a novel and potent Notch inhibitor.
In a xenograft tumor model, LY3039478 inhibit N1ICD cleavage and expression of Notch-regulated genes in the tumor microenvironment. LY3039478 is being investigated in Phase I. |
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| BCC2109 | Glimepiride |
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Potent K<sub>ir</sub>6 (K<sub>ATP</sub>) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac K<sub>ir</sub>6 channels with an IC<sub>50</sub> of 6.8 nM.
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| BCC2118 | Marimastat |
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Broad spectrum inhibitor of MMPs (IC<sub>50</sub> values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Inhibits peritoneal dissemination of human gastric cancer cells <em>in vivo</em> through inhibition of tumor angiogenesis.
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