Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN7589 | 6-Ethoxydihydrosanguinarine |
| 1. 6-Ethoxydihydrosanguinarine shows human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity, with IC50 values of 0.83 +/- 0.04 microM and 4.20 +/- 0.19 microM, respectively. | |
| BCN7590 | 5,6,7-Trimethoxycoumarin |
| 1. 5,6,7-Trimethoxycoumarin can improve gastroprotective effects, and it has low toxicity and minimal effects on drug-metabolizing enzymes. 2. 5,6,7-Trimethoxycoumarin shows moderate inhibitory activity against Micrococcus luteus. 3. 5,6,7-Trimethoxycoumarin displays an intermediate cytotoxic effects against brine shrimp larvae. | |
| BCN6439 | N-(3-Methoxybenzyl)(9Z,12Z,15Z)-octadeca-9,12,15-trienamide |
| 1. Kaji-ichigoside F1 exhibits in vivo hepatoprotective effects, it inhibited d-GalN-induced cytotoxicity in primary cultured mouse hepatocytes with the IC50 of14.1uM. 2. Kaji-ichigoside F1 shows antiinflammatory/antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats. | |
| BCN7596 | Albatrelin G |
| 1. Albatrelin G shows weak cytotoxic activity to cell lines HL-60, SMMC-7721, A-549, and MCF-7, in vitro. | |
| BCN7598 | Ciwujiatone |
| 1. Ciwujiatone exhibits significant activities against colon cancer cell lines SW480 and SW620. | |
| BCN7613 | Isoiridogermanal |
| 1. Isoiridogermanal shows similar cytotoxicity with IG(50) around 11 microM and 23 microM against MCF-7 and C32 cell lines, respectively. | |
| BCN7615 | Bruceine B |
| 1. Bruceine B demonstrates significant inhibitory activities against HL-60, SMMC-7721, A-549, and MCF-7 tumor cells. 2. Bruceine B shows strong antiviral activities, with IC(50) values in the range of 3.42-5.66 microM. 3. Bruceine A and bruceine B show strong antitrypanosomal activities with IC(50) values in the range of 2.9-17.8nM. 4. Bruceine B exhibits potent anti-malarial activities with high selective toxicities. 5. Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion, may have anti-inflammatory activity, it can inhibit neutrophil adhesion to lipopolysaccharide-stimulated HUVEC and T cell adhesion to TNF-stimulated HUVEC. | |
| BCN7616 | Bruceantinol |
| 1. Bruceantinol has antiviral activity, it can inhibit pepper mottle virus in pepper. 2. Bruceantinol shows in vitro inhibitory activity against Trypanosoma evansi. 3. Bruceantinol shows antibabesial activity against Babesia gibsoni in vitro, with the IC50 value of 12 ng/mL. | |
