Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN7637 | Kielcorin |
| 1. Kielcorin shows antibacterial activity against strain EMRSA-16. 2. Kielcorin shows in vitro anti-inflammatory (respiratory burst) inhibiting activities using isolated human neutrophils (IC (50) = 965.21 ± 65.80 uM). 3. trans-Kielcorin has hepatoprotective activity, it can prevent tert-butylhydroperoxide-induced lipid peroxidation and cell death in freshly isolated rat hepatocytes. | |
| BCN7638 | 7beta-(3-Ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone |
| 1. 7beta-(3-Ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone shows diacylglycerol acyltransferase (DGAT)1 inhibition with IC(50) values of 47.0 microM (for rat liver microsomes) and 160.7 microM (for HepG2 cell microsomes), respectively. | |
| BCN7639 | 5,6-Desmethylenedioxy-5-methoxyaglalactone |
| 1. 5,6-Desmethylenedioxy-5-methoxyaglalactone is cytotoxic to small cell lung cancer (NCI-H187) cell line. 2. 5,6-Desmethylenedioxy-5-methoxyaglalactone has antimycobacterial activity against Mycobacterium tuberculosis H(37)Ra. | |
| BCN7641 | Niazimicin |
| 1. Niazimicin has potent antitumor promoting activity in the two-stage carcinogenesis in mouse skin using 7,12-dimethylbenz(a)anthracene (DMBA) as initiator and TPA as tumor promoter, it is proposed to be a potent chemo-preventive agent. 2. Niazimicin shows antimicrobial activity. 3. Niazimicin has hypotensive and spasmolytic activities. 4. Niazimicin are NF-B and PI3K inhibitors. | |
| BCN7642 | 1,5,6-Trihydroxyxanthone |
| 1. 1,5,6-Trihydroxyxanthone exhibits antibacterial activity against Gram-positive bacteria. | |
| BCN7643 | Excisanin A |
| 1. Excisanin A can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. 2. ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells. 3. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability. 3. Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the cleavage of caspase-3 and the proteolytic degradation of poly (ADP-ribose) polymerase (PARP). | |
| BCN7645 | Aphadilactone C |
| 1. Aphadilactone C shows potent and selective inhibition against the diacylglycerol O-acyltransferase-1 (DGAT-1) enzyme (IC50 = 0.46 ± 0.09 uM, selectivity index > 217). 2. Aphadilactone C shows significant antimalarial activity with the IC50 value of 170 ± 10 nM. | |
| BCN7646 | Aphadilactone B |
| 1. Aphadilactone B shows significant antimalarial activity with the IC50 value of 1350 ± 150 nM. | |
