Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 385 - 392 of 9359 hot products
| Catalog No. | Product Name |
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| BCC2305 | PluriSIn #1 (NSC 14613) |
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Stearoyl-CoA desaturase 1 (SCD1) inhibitor. Used to selectively eliminate undifferentiated human pluripotent stem cells (hPSCs) from culture; induces ER stress, attenuates protein synthesis and induces apoptosis in hPSCs. Prevents teratoma formation in immunocompromised mice.
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| BCC2306 | Anagrelide HCl |
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Potent type III phosphodiesterase (PDE3) inhibitor (IC50 = 36 nM). Inhibits platelet aggregation and produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation.
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| BCC2307 | Pyrimethamine |
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Potent inhibitor of multidrug and toxin extrusion (MATE) transporters (Ki values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR) and STAT3. Decreases proliferation of human autosomal dominant polycystic kidney disease cells.
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| BCC2308 | UK 383367 |
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Potent and selective inhibitor of BMP-1 (procollagen C-proteinase; PCP) (IC50 = 44 nM). Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).
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| BCC2309 | Tosedostat (CHR2797) |
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Aminopeptidase inhibitor (IC<sub>50</sub> values are 100, 150, 220, > 1000, > 5000, > 10000 and > 30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA<sub>4</sub> hydrolase and MetAP2 respectively). Potently inhibits tumor cell proliferation in a variety of tumor cell lines <em>in vitro</em> and <em>in vivo</em>.
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| BCC2310 | Varespladib (LY315920) |
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Selective secreted phospholipase A2 (sPLA2) inhibitor (IC50 = 50 - 750 nM for a range of sPLA2 isoforms). Has no effect on cytosolic PLA2 or COX-1 and COX-2 activity. Attenuates sPLA2-induced thromboxane formation in bronchoalveolar lavage (BAL) cells. Also suppresses sPLA2-induced contractions of lung pleural strips ex vivo. Orally available.
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| BCC2312 | U-104 |
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Potent carbonic anhydrase (CA) inhibitor (Ki values are 4.5, 45.1, 5080 and 9640 nM for CA XII, CA IX, CA I and CA II respectively in MDA-MB-231 cells). Inhibits tumor metastasis in the rat 4T1 metastasis model.
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| BCC2314 | Topiramate |
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Anticonvulsant. Antagonizes GluR5 kainate receptors (IC<sub>50</sub> = 0.46 <span class='symbol'>μ</span>M), acts as a positive allosteric modulator of GABA<sub>A</sub> receptor-mediated currents, inhibits Na<sub>v</sub> channels (IC<sub>50</sub> = 48.9 <span class='symbol'>μ</span>M) and inhibits L-type Ca<sup>2+</sup> channels. Also inhibits carbonic anhydrase (CA) (K<sub>i</sub> values are 0.1 and 0.2 <span class='symbol'>μ</span>M at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.
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