Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 377 - 384 of 9359 hot products
| Catalog No. | Product Name |
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| BCC2282 | Rolipram |
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Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC<sub>50</sub> = 2.0 <span class='symbol'>μ</span>M). Discriminates between two conformational states of PDE4 isoenzymes. Separate isomers (<em>R</em>)-(-)-Rolipram</a> and (<em>S</em>)-(+)-Rolipram</a> are available.
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| BCC2284 | Isotretinoin |
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Endogenous agonist for retinoic acid receptors. Promotes neurite outgrowth, cell differentiation and inhibits proliferation in a neuroblastoma cell line. Also increases protein expression levels of <em>MYCN</em> and retinoic acid receptor-<span class='symbol'>β</span>. Anti-inflammatory.
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| BCC2286 | Nepicastat (SYN-117) HCl |
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Potent and selective dopamine <span class='symbol'>β</span>-hydroxylase (DBH) inhibitor (IC<sub>50</sub> = 9 nM) . Selective for DBH over 12 other enzymes. Decreases noradrenaline and increases dopamine levels in tissues and plasma in hypertensive rats. Prevents progressive left ventricular dysfunction in an <em>in vivo</em> heart failure model. Also potentiates the stimulus effects of cocaine without producing cocaine-like effects in rats. Orally bioavailable.
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| BCC2287 | CPI-613 |
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Pyruvate dehydrogenase (PDH) and <span class='symbol'>α</span>-ketoglutarate dehydrogenase (KGDH) inhibitor. Disrupts tumor cell mitochondrial metabolism, and increases mitochondrial reactive oxygen species (ROS) production in H460 lung carcinoma cells. Has no effect on KGDH activity in normal bronchial epithelial cells. Induces cell death of multiple tumor cell lines selectively over normal cells <em>in vitro</em>. Inhibits tumor growth of H460 and BxPC-3 tumor cell xenografts in mice.
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| BCC2290 | Mycophenolate Mofetil |
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Immunosuppressant prodrug of mycophenolic acid (MPA). Hydrolyzed by esterases to release MPA (a reversible inhibitor of inosine monophosphate dehydrogenase). Used to prevent organ rejection after transplantation. Displays inhibitory activity of lymphocyte functions. Inhibits type 1 collagen expression, enhances MMP-1 expression, and reduces <span class='symbol'>α</span>-smooth muscle actin gene expression.
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| BCC2291 | Cilostazol |
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Potent phosphodiesterase III A (PDE3A) inhibitor (IC<sub>50</sub> = 0.2 <span class='symbol'>μ</span>M) and inhibitor of adenosine uptake. Has antimitogenic, antithrombotic, vasodilatory and cardiotonic properties <em>in vivo</em>. Also affects lipid levels <em>in vivo</em>.
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| BCC2301 | Methotrexate |
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Cytotoxic agent. Inhibits thymidylate synthetase and de novo purine synthesis. Potent folic acid antagonist; inhibits dihydrofolate reductase. Also inhibits Ras carboxyl methylation in DKOB8 cells, leading to decreased p44 and Akt activation.
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| BCC2303 | S- (+)-Rolipram |
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Less active enantiomer of the PDE4 inhibitor rolipram. (<em>R</em>)-(-)-Rolipram also available.
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