Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN7567 | Geranylacetone |
| 1. Geranylacetone is a potent inhibitor of β-secretase (BACE1), it may have potential treatment for Alzheimer's disease. 2. Geranylacetone is a TRPV1 agonist. | |
| BCN7572 | 4beta-Hydroxywithanolide E |
| 1. 4beta-Hydroxywithanolide E(4bHWE) affects alternative splicing by modulating splicing factors and histone modifications, and provides a novel view of the antitumor mechanism of 4bHWE. 2. 4bHWE can inhibit the growth of colon cancer monolayer and spheroid cultures. 3. 4bHWE decreases inflammatory responses by inhibiting the NF-κB signaling in diabetic mouse adipose tissue, it also can improve impaired glucose tolerance, thus, it is a useful natural anti-inflammatory compound to attenuate progression of diabetes and obesity. 4. 4bHWE assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent. | |
| BCN7575 | Cornoside |
| 1. Cornoside and Iridoids are chemosystematic markers. | |
| BCN7579 | Nyasol |
| 1. (-)-Nyasol exhibits the half maximal inhibitory concentration (IC50) value of 17.6 uM against D-glycero-α-D-manno-heptose-1-phosphate guanylyltransferase (HddC). 2. Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. 3. Nyasol shows anti-inflammatory properties by inhibiting iNOS expression. 4. Nyasol has antifungal activity, it is significantly effective in suppressing the Phytophthora blight on pepper plants. 5. (+)-Nyasol has antiprotozoal activity, it potently inhibits the growth of Leishmania major promastigotes, the IC50 being 12 microM, and moderately inhibits Plasmodium falciparum schizonts with the IC50 49 microM. | |
| BCN7581 | 6-Methoxydihydrosanguinarine |
| 1. 6-Methoxydihydrosanguinarine may have anti-inflammatory effects via the inhibition of NO and IL-6 expression through the down-regulation of MAP kinase (ERK1/2, p38) phosphorylation in RAW 264.7 cells. 2. 6-Methoxydihydrosanguinarine has antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentrations (MICs) ranging from1.9 to 3.9 microg/ml. 3. 6-Methoxydihydrosanguinarine shows a dose-dependent effect at 1-10 microM on causing apoptotic cell death in HT29 colon carcinoma cells (IC50 = 5.0+/-0.2 microM). 4. 6-Methoxydihydrosanguinarine shows strong nematocidal activities, however, it is highly cytotoxic; thus, the prospect of its direct application is low. | |
| BCN7583 | Matairesinoside |
| Matairesinoside is a natural product from Styrax japonica. | |
| BCN7585 | 1,2,5-Trihydroxyxanthone |
| 1. 1,2,5-Trihydroxyxanthone has antioxidative properties. | |
| BCN7588 | 2,6,4'-Trihydroxy-4-methoxybenzophenone |
| 1. 2,6,4'-Trihydroxy-4-methoxybenzophenone has neurotrophic activity, it induced neurite outgrowth in PC-12 cells at concentration of 50 microg/ml. 2. 2,6,4'-Trihydroxy-4-methoxybenzophenone shows weak inhibitory activity of testosterone 5alpha-reductase . 3. 2,6,4′-Trihydroxy-4-methoxybenzophenone exhibits low cytotoxic effect against HeLa and 3T3 cell lines with IC50 values of 132 ug/ml and 158 ug/ml, repectively. 4. 2,6,4′-Trihydroxy-4-methoxybenzophenone shows significant inhibition of pancreatic lipase activity. 5. 2,6,4'-Trihydroxy-4-methoxybenzophenon shows antioxidant activity on DPPH with IC50 of 10.57 ug/mL. | |
