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Hot Products

Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.

Hot products from the professional high-purity natural products manufacturer

Cat.No.	Product Name
BCN7546	2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran
1. 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran shows mushroom tyrosinase inhibitory activity with an IC50 value of 5.2 micronM and acts as a competitive inhibitor. 2. 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran shows radical scavenging activities.
BCN7549	1,3,7-Trihydroxy-2-methoxyxanthone
1. 1,3,7-Trihydroxy-2-methoxyxanthone shows different anti-oxidation activities.
BCN7553	Grifolin
1. Grifolin enhances the differentiation and proliferation of oligodendrocyte precursor cells (OPCs) in oxygen/glucose deprivation (OGD)-induced injury by altering the expressions of Id2 and Olig2. 2. Grifolin has anti-cancer effects, it induces apoptosis and promotes cell cycle arrest in the A2780 human ovarian cancer cell line via inactivation of the ERK1/2 and Akt pathways. 3. Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1α and Fra-1 / LSF- MMP2 / CD44 axes. 4. Grifolin possesses antimicrobial activities against Bacillus cereus and Enterococcus faecalis. 5. Grifolin shows antifungal activity against plant pathogenic fungi (Erysiphe graminis). 6. Grifolin exhibits in vitro antileishmanial activity. 7. Grifolin shows hypocholesterolemic action on rats fed with a High-cholesterol diet.
BCN7556	Cypellocarpin C
1. Cypellocarpin C shows potent in vitro antitumor-promoting activity, it also can suppress an in vivo two-stage carcinogenesis induced with nitric oxide and TPA on mouse skin.
BCN7558	7-O-Acetylbonducellpin C
1. 7-O-Acetylbonducellpin C may exhibit significant inhibition of nitric oxide production of RAW264.7 macrophages stimulated by lipopolysaccharide (LPS).
BCN7562	Dehydrovomifoliol
1. Dehydrovomifoliol could be a marker of Polish heather honey. 2. Dehydrovomifoliol exhibits moderate acetylcholinesterase (AChE) inhibitory activities. 3. Dehydrovomifoliol shows significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and the IC(50) values in the range 3.7-8.1 microM.
BCN7563	Kobusin
Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and peroxynitrite scavenging potential. Kobusin can mildly reduce gastrointestinal motility in mice, it activates CFTR and CaCCgie chloride channel activities in mouse colonic epithelia and shows inhibitory effects toward ANO1/CaCC-mediated short-circuit currents in ANO1/CaCC-expressing FRT cells.
BCN7564	4'-O-Methylnyasol
1. 4'-O-Methylnyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells.