Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 345 - 352 of 9359 hot products
| Catalog No. | Product Name |
|---|---|
| BCC2220 | Thioguanine |
|
Anticancer and immunosuppressive agent often used to treat immune disorders and leukemia. Displays cytotoxic and antineoplastic properties; disrupts cytosine methylation by DNA methyltransferases after incorporation into DNA. Selectively kills BRCA2-defective tumors in a xenograft model. Also facilitates proteasome-mediated degradation of DNA (cytosine-5)-methyltransferase 1 (DNMT1).
|
|
| BCC2223 | EX 527 (SEN0014196) |
|
Selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Enhances p53 acetylation in response to DNA damaging agents.
|
|
| BCC2224 | Sirtinol |
|
Cell-permeable, selective sirtuin deacetylase inhibitor (IC<sub>50</sub> values are 38, 68 and 131 <span class='symbol'>μ</span>M at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells <em>in vitro</em>.
|
|
| BCC2225 | PFI-1 (PF-6405761) |
|
Potent BET bromodomain inhibitor; exhibits inhibitory activity at bromodomain-containing protein (BRD) 2 and BRD4 (IC50 values are 98 and 220 nM respectively). Induces apoptosis and G1 cell cycle arrest in BET inhibitor-sensitive cell lines (MV4;11). Also downregulates Aurora B expression in MV4;11 cells. Cell permeable.
|
|
| BCC2228 | 2-Methoxyestradiol (2-MeOE2) |
|
Apoptotic, antiproliferative and antiangiogenic agent, <em>in vitro</em> and <em>in vivo</em>; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-<span class='symbol'>κ</span>B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.
|
|
| BCC2229 | IOX2(Glycine) |
|
Potent inhibitor of HIF-1<span class='symbol'>α</span> prolyl hydroxylase-2 (PHD2) (IC<sub>50</sub> = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3. Cell permeable.
|
|
| BCC2230 | GSK J4 HCl |
|
Histone lysine demethylase (KDM) inhibitor; blocks demethylation of histone H3K27. Attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC<sub>50</sub> = 9 <span class='symbol'>μ</span>M for the inhibition of TNF<span class='symbol'>α</span> release). Cell permeable. Ethyl ester derivative of GSK J1.
|
|
| BCC2231 | GSK J1 |
|
Potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) (IC<sub>50</sub> values are 28 and 53 nM respectively). Also inhibits KDM5B, KDM5C and KDM5A (IC<sub>50</sub> values are 170, 550 and 6,800 nM respectively). Exhibits no activity against a panel of other histone demethylases (IC<sub>50</sub> >20 <span class='symbol'>μ</span>M), and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30 <span class='symbol'>μ</span>M. Ethyl ester derivative also available.
|
|