Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 369 - 376 of 9359 hot products
| Catalog No. | Product Name |
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| BCC2267 | GW0742 |
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Potent and highly selective PPAR<span class='symbol'>δ</span> agonist. EC<sub>50</sub> values are 0.001, 1.1 and 2 <span class='symbol'>μ</span>M for transactivation of human PPAR<span class='symbol'>δ</span>, -<span class='symbol'>α</span>, and -<span class='symbol'>γ</span> receptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty acid oxidation and protects against ischemia/reperfusion injury in neonatal and adult cardiomyocytes.
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| BCC2268 | GW501516 |
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Potent and selective PPAR<span class='symbol'>δ</span> agonist (EC<sub>50</sub> = 1.2 nM). Displays <1000-fold selectivity over other ppar subtypes. increases abc a1 transporter expression and induces apolipoprotein a1-mediated cholesterol efflux <em>in vitro</em>. Also increase serum HDL cholesterol and lowers small, dense LDL levels in obesity <em>in vivo</em> models.
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| BCC2270 | PF-4981517 |
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Potent and selective inhibitor of CYP3A4 (IC<sub>50</sub> values are 0.03, 17 and 70 <span class='symbol'>μ</span>M for CYP3A4, CYP3A5 and CYP3A7 respectively).
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| BCC2272 | Ketoconazole |
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Inhibitor of cytochrome P450c17. Enhances the formation of myelin basic protein-positive oligodendrocytes from oligodendrocyte progenitor cells in vitro and promotes remyelination in vivo. Also an antifungal agent. Brain penetrant.
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| BCC2275 | Voriconazole |
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Triazole antifungal agent. Displays potent activity against Candida, Cryptococcus and Aspergillus species.
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| BCC2276 | Sildenafil Citrate |
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Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro.
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| BCC2278 | Pioglitazone HCl |
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Selective PPAR<span class='symbol'>γ</span> agonist (EC<sub>50</sub> = 0.69 <span class='symbol'>μ</span>M). Thiazolidinedione (TZD) derivative and antidiabetic agent; improves insulin sensitivity.
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| BCC2281 | Tadalafil |
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Potent and highly selective PDE5 inhibitor (IC50 = 5 nM). Exhibits > 2000-fold selectivity for PDE5 over PDEs 1,2,3 and 4 and 1000-fold selectivity over PDE6. Reduces blood pressure in hypertensive rats. Also delays tumor growth in a mouse model via inhibition of MDSC-mediated immunosuppression. Orally bioavailable.
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