Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 409 - 416 of 9359 hot products
| Catalog No. | Product Name |
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| BCC2344 | L-685,458 |
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Potent and selective <span class='symbol'>γ</span>-secretase inhibitor (IC<sub>50</sub> = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of A<span class='symbol'>β</span>40 and A<span class='symbol'>β</span>42 peptides (IC<sub>50</sub> values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling <em>in vitro</em>.
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| BCC2345 | MRK 560 |
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<span class='symbol'>γ</span>-secretase inhibitor; inhibits proteolytic cleavage of amyloid precursor protein (APP) over the Notch pathway. Reduces levels of A<span class='symbol'>β</span> in the brain (inhibits A<span class='symbol'>β</span>40 and A<span class='symbol'>β</span>42 in SH-SY5Y neuroblastoma cells with an IC<sub>50</sub> of 0.65 nM); attenuates plaque deposition. Orally bioavailable.
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| BCC2346 | Begacestat |
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<span class='symbol'>γ</span>-secretase inhibitor; selectively inhibits cleavage of amyloid precursor protein (APP) over Notch. Lowers levels of A<span class='symbol'>β</span>42 and A<span class='symbol'>β</span>40 (EC<sub>50</sub> values are 12.4 and 14.8 nM respectively in cells expressing human recombinant APP). Orally active.
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| BCC2347 | Fumagillin |
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Antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation <em>in vitro</em> and tumor-induced angiogenesis <em>in vivo</em>. Also inhibits tumor growth in mice.
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| BCC2348 | SC 57461A |
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Potent and selective inhibitor of LTA<sub>4</sub> hydrolase. Does not inhibit other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC<sub>4</sub> synthase and 5-lipoxygenase. Potently inhibits LTB<sub>4</sub> production in whole blood (IC<sub>50</sub> = 49 nM). Orally active.
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| BCC2349 | Spinorphin |
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Endogenous peptide; inhibits enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase III, neprilysin) and angiotensin-converting enzyme. Displays antinociceptive effects in mice.
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| BCC2350 | Acetyl-Calpastatin (184-210) (human) |
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Selective calpain inhibitor. Strongly inhibits calpain I (K<sub>i</sub> = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (K<sub>i</sub> = 6 <span class='symbol'>μ</span>M). Increases secretion of amyoid <span class='symbol'>β</span>-protein (A<span class='symbol'>β</span>) 42, A<span class='symbol'>β</span>40 and A<span class='symbol'>β</span>42 ratio.
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| BCC2351 | Calpeptin |
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Potent, cell-permeable inhibitor of the Ca<sup>2+</sup>-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases.
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