Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 465 - 472 of 9359 hot products
| Catalog No. | Product Name |
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| BCC2409 | MIRA-1 |
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Restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner <em>in vitro</em> (IC<sub>50</sub> = 10<span class='symbol'>μ</span>M).
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| BCC2410 | NSC 146109 hydrochloride |
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Cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay.
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| BCC2411 | PhiKan 083 |
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p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Slows rate of thermal denaturation of p53-Y220C.
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| BCC2412 | Pifithrin-μ |
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Inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Reduces cell death induced by <span class='symbol'>γ</span>-radiation <em>in vitro</em> and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity.
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| BCC2413 | PRIMA-1 |
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Selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of tumors with mutant p53.
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| BCC2414 | PRIMA-1MET |
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Methylated derivative of PRIMA-1. Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.
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| BCC2416 | SJ 172550 |
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MDMX inhibitor. Reversibly binds MDMX (EC<sub>50</sub> = 2.3 <span class='symbol'>μ</span>M). Inhibits the MDMX-p53 interaction in cultured retinoblastoma cells; frees p53 to induce apoptosis.
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| BCC2417 | WR 1065 |
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Cell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway. Activates p21<sup>waf-1</sup> and MDM2, represses transcription of Myc and thymidine kinase, and inhibits DNA topoisomerase II<span class='symbol'>α</span>. Induces cell cycle arrest and exhibits cytoprotective activity towards normal cells but not cancer cells <em>in vivo</em>. Also exhibits broad spectrum antiviral activity <em>in vitro</em>.
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