Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 505 - 512 of 9359 hot products
| Catalog No. | Product Name |
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| BCC2453 | JW 55 |
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Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin; inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells in vitro.
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| BCC2454 | NU 1025 |
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Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively.
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| BCC2455 | WIKI4 |
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Inhibitor of Wnt/<span class='symbol'>β</span>-catenin signaling (EC<sub>50</sub> ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC<sub>50</sub> ~15 nM); prevents the ubiquitination and degradation of axin.
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| BCC2456 | Calcineurin Autoinhibitory Peptide |
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Selective inhibitor of Ca<sup>2+</sup>-calmodulin-dependent protein phosphatase (calcineurin) (IC<sub>50</sub> ~ 10 <span class='symbol'>μ</span>M). Does not inhibit PP1, PP2A or CaM kinase II (IC<sub>50</sub> > 100 mM).
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| BCC2457 | Calyculin A |
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Potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC<sub>50</sub> = 0.3 - 0.7 nM) and protein phosphatase 2A (IC<sub>50</sub> = 0.5 - 1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C.
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| BCC2458 | Ceramide |
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A potent modulator of cell proliferation and differentiation. Activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) <em>in vitro</em>.
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| BCC2459 | DL-AP3 |
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Competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.
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| BCC2460 | Fostriecin sodium salt |
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Potent inhibitor of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC<sub>50</sub> values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC<sub>50</sub> = 40 <span class='symbol'>μ</span>M) and protein phosphatase type 1 (PP1) (IC<sub>50</sub> = 131 <span class='symbol'>μ</span>M) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active <em>in vivo</em>. Originally identified as an antitumor antibiotic from <em>Streptomyces pulveraceous</em>.
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