Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 521 - 528 of 9359 hot products
| Catalog No. | Product Name |
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| BCC2471 | Thiolutin |
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Antibiotic; inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC50 = 0.83 mM) and subsequently reduces paxillin levels. Suppresses tumor cell-induced angiogenesis.
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| BCC2473 | TPCA-1 |
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Potent, selective inhibitor of I<span class='symbol'>κ</span>B kinase (IKK) <span class='symbol'>β</span> (IC<sub>50</sub> = 17.9 nM) that displays > 22-fold selectivity over IKK<span class='symbol'>α</span> and > 550-fold selectivity over other kinases and enzymes. Inhibits production of pro-inflammatory cytokines <em>in vitro</em> and <em>in vivo</em> and inhibits NF-<span class='symbol'>κ</span>B nuclear localization. Reduces the severity and onset of collagen-induced arthritis; anti-inflammatory.
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| BCC2474 | SP 600125 |
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Selective JNK inhibitor. Competitively and reversibly inhibits JNK1, 2 and 3 (IC<sub>50</sub> = 40 - 90 nM) with negligible activity at ERK2, p38<span class='symbol'>β</span> and a range of enzymes. Active <em>in vivo</em>. Exhibits reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis. Prevents BMP9-induced osteogenic differentiation of MSCs. Essential component of medium for maintaining stem cells in naive pluripotent state. Available as part of the MAPK Inhibitor.
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| BCC2475 | KU 55933 |
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Potent, selective and competitive ATM kinase inhibitor (Ki = 2.2 nM, IC50 values are 13, 2500, 9300, 16600, > 100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro. Acts as a radio- and chemosensitizer for the treatment of cancer.
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| BCC2476 | Asenapine |
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Novel psychopharmacologic agent. Displays antagonist activity at 5-HT, dopamine, noradrenalin and histamine receptor subtypes (pK<sub>i</sub> values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8.21 for 5-HT<sub>1A</sub>, 5-HT<sub>1B</sub>, 5-HT<sub>2A</sub>, 5-HT<sub>2B</sub>, 5-HT<sub>2C</sub>, 5-HT<sub>5A</sub>, 5-HT<sub>6</sub>, 5-HT<sub>7</sub>, D<sub>1</sub>, D<sub>2L</sub>, D<sub>2S</sub>, D<sub>3</sub>, D<sub>4</sub>, <span class='symbol'>α</span><sub>1A</sub>, <span class='symbol'>α</span><sub>2A</sub>, <span class='symbol'>α</span><sub>2B</sub>, <span class='symbol'>α</span><sub>2C</sub>, H<sub>1</sub> and H<sub>2</sub> receptors respectively). Displays no appreciable affinity for muscarinic receptors. Exhibits potent activity in animal models predictive of antipsychotic efficacy.
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| BCC2480 | Edaravone |
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A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity. Inhibits autophagy.
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| BCC2481 | Bicalutamide |
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Orally active non-steroidal androgen receptor antagonist (IC<sub>50</sub> = 190 nM). Displays peripheral selectivity and does not effect serum levels of LH and testosterone. Exhibits potent anticancer activity <em>in vivo</em>.
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| BCC2482 | GDC-0879 |
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Potent and selective B-Raf inhibitor (IC50 = 0.13 nM against purified B-Raf V600E). Activity reduces phospho-ERK (pERK) levels (IC50 = 63 nM in the Malme-3M cell line). Inhibits the Raf/MEK/ERK signaling pathway in V600E B-Raf mutant cell lines. Does not activate apoptotic pathways in A375 or Colo205 cell lines. Orally bioavailable.
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