Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 473 - 480 of 9359 hot products
| Catalog No. | Product Name |
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| BCC2418 | TC-A 2317 hydrochloride |
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Potent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC50 values > 1000 nM). Exhibits good cell permeability and antitumor activity.
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| BCC2420 | KD 5170 |
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Class I and II histone deacetylase (HDAC) inhibitor (IC50 = 0.045 μM; EC50 = 0.025 μM in HeLa screening and HeLa cell-based assays, respectively). Exhibits broad spectrum inhibition of HDAC classes I and II in assays using purified recombinant human isoforms. Displays less potent inhibition of HDAC2 (IC50 values are 0.014, 0.020, 0.026, 0.075 and 2.0 μM for HDAC6, HDAC1, HDAC4, HDAC3 and HDAC2 respectively). Displays cytotoxicity against numerous cell lines derived from human tumors. Orally available.
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| BCC2421 | LMK 235 |
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Selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor (IC<sub>50</sub> values are 4.22, 11.9, 55.7, 320, 852, 881, and 1278 nM for HDAC 5, 4, 6, 1, 11, 2, and 8, respectively). Demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC<sub>50</sub> = 0.49 and 0.32 <span class='symbol'>μ</span>M respectively).
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| BCC2422 | NCH 51 |
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Histone deacetylase (HDAC) inhibitor. Inhibits growth of various cancer cells <em>in vitro</em> (EC<sub>50</sub> = 1.1 - 9.1 <span class ='symbol'>μ</span>M).
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| BCC2423 | NSC 3852 |
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Histone deacetylase inhibitor. Causes cell differentiation and antiproliferative activity in MCF-7 human breast cancer cells in vitro and displays antitumor activity in vivo.
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| BCC2424 | Pyroxamide |
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Inhibitor of histone deacetylase (HDAC); potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.
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| BCC2425 | SBHA |
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Histone deacetylase (HDAC) inhibitor (ID<sub>50</sub> values are 0.25 and 0.3 <span class='symbol'>μ</span>M for HDAC1 and HDAC3 respectively). Potentiates the cytostatic effects of 5-Fluorouracil in colorectal cancer cells.
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| BCC2426 | TC-H 106 |
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Class I histone deacetylase (HDAC) inhibitor (IC50 values are 150, 370, 760 and 5000 nM for HDAC1, HDAC3, HDAC2 and HDAC8 respectively). Exhibits slow, tight-binding inhibitory activity. Displays no activity against class II HDACs. Brain penetrant.
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