Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 489 - 496 of 9359 hot products
| Catalog No. | Product Name |
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| BCC2437 | 1,2,3,4,5,6-Hexabromocyclohexane |
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Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 <span class='symbol'>μ</span>M of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 <span class='symbol'>μ</span>M elimates nearly all JAK2 activity. Non-cytotoxic at 100 <span class='symbol'>μ</span>M.
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| BCC2438 | Cercosporamide |
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Potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Blocks eIF4E phosphorylation; exhibits antiproliferative and proapoptotic activity in cancer cells in vitro. Also inhibits Pkc1. Orally bioavailable.
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| BCC2439 | Cucurbitacin I |
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Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.
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| BCC2440 | Lestaurtinib |
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Potent JAK2, FLT3 and TrkA inhibitor (IC50 values are 0.9, 3 and < 25 nM, respectively). Also inhibits Aurora kinase A and B (IC50 values are 8.1 and 2.3 nM, respectively) and prevents STAT5 phosphorylation (IC50 = 20 - 30 nM). Exhibits antiproliferative activity in vitro (IC50 = 30 - 100 nM in HEL92.1.7 cells) and is effective against myeloproliferative disorders in vivo.
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| BCC2441 | NSC 33994 |
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Selective inhibitor of JAK2 (IC<sub>50</sub> = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 <span class='symbol'>μ</span>M.
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| BCC2442 | SD 1008 |
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JAK2/STAT3 signaling pathway inhibitor. Inhibits activation of STAT3, JAK2 and Src. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.
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| BCC2443 | TCS 21311 |
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Potent JAK3 inhibitor (IC<sub>50</sub> = 8 nM). Selective for JAK3 over JAK1, JAK2 and TYK2 (IC<sub>50</sub> values are 1017, 2550 and 8055 nM respectively). Also inhibits GSK-3<span class='symbol'>β</span>, PKC<span class='symbol'>α</span> and PKC<span class='symbol'>θ</span> (IC<sub>50</sub> values are 3, 13 and 68 nM respectively).
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| BCC2444 | ZM 449829 |
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Potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site. pIC<sub>50</sub> values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Inhibits STAT-5 phosphorylation and T cell proliferation.
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