Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 513 - 520 of 9359 hot products
| Catalog No. | Product Name |
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| BCC2461 | Fumonisin B1 |
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Mycotoxin produced by <em>Fusarium moniliforme</em>. Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC<sub>50</sub> ~ 75 nM). Also inhibits protein phosphatases; IC<sub>50</sub> values are 80, 300, 400, 500 and 3000 <span class='symbol'>μ</span>M for PP5, PP2C<span class='symbol'>α</span>, PP2A, PP1<span class='symbol'>γ</span>2 and PP2B respectively.
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| BCC2463 | NFAT Inhibitor |
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Selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Does not disrupt other calcineurin-dependent pathways. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells.
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| BCC2464 | Okadaic acid |
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Potent inhibitor of protein phosphatase 1 (IC<sub>50</sub> = 3 nM) and protein phosphatase 2A (IC<sub>50</sub> = 0.2-1 nM). Displays > 100,000,000-fold selectivity over PP2B and PP2C. Tumor promoter. Shown to activate atypical protein kinase C in adipocytes.
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| BCC2465 | Sal 003 |
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Cell-permeable inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit <span class='symbol'>α</span> (eIF2<span class='symbol'>α</span>). Analog of salubrinal with improved aqueous solubility. Shown to prevent the induction of hippocampal long-term potentiation (LTP) and memory formation (LTM) in mice.
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| BCC2466 | Alexidine dihydrochloride |
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Selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC<sub>50</sub> = 1.08 <span class='symbol'>μ</span>M <em>in vitro</em>). Stimulates increased insulin secretion by <span class='symbol'>β</span>-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells. Also preserves functional hematopoietic stem cells <em>ex vivo</em>.
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| BCC2467 | BVT 948 |
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<em></em>Non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC<sub>50</sub> = 0.09 - 1.7 <span class='symbol'>μ</span>M); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling <em>in vitro</em> and insulin tolerance in ob/ob mice <em>in vivo</em>. Also inhibits several cytochrome P450 isoforms (IC<sub>50</sub> < 10 <span class='symbol'>μ</span>M).
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| BCC2468 | NSC 87877 |
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Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC<sub>50</sub> values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 <span class='symbol'>μ</span>M for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.
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| BCC2470 | Mithramycin A |
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Anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg<sup>2+</sup> or Zn<sup>2+</sup>, inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.
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