Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 449 - 456 of 9359 hot products
| Catalog No. | Product Name |
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| BCC2391 | ARRY 520 trifluoroacetate |
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Potent kinesin spindle protein (KSP) inhibitor (IC<sub>50</sub> = 6 nM); selective for KSP over >250 other receptors and kinases at a concentration of 10 <span class='symbol'>μ</span>M. Displays robust antitumor activity in bortezomib-resistant xenografts either alone or in combination with bortezomib. Induces degradation of Mcl-1; exhibits comparable cytotoxic activity to taxol in epithelial ovarian cancer cells. Active <em>in vivo</em>.
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| BCC2393 | Bax inhibitor peptide P5 |
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Originally reported to be a cell-permeable synthetic peptide inhibitor of Bax that blocks apoptosis. Also available: Bax inhibitor peptide V5 and Negative control .
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| BCC2394 | Bax inhibitor peptide V5 |
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Cell-permeable synthetic peptide inhibitor of Bax conformational change and mitochondrial translocation. Designed based on the Bax-binding domain of human Ku70. Inhibits Bax-mediated apoptosis <em>in vitro</em>. Shown to inhibit anti-cancer drug-induced apoptosis <em>in vitro</em>. Negative control available.
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| BCC2395 | Bax inhibitor peptide, negative control |
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Negative control peptide for the Bax inhibitor peptide V5 P5, which inhibit Bax translocation to mitochondria and Bax-mediated apoptosis <em>in vitro</em>.
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| BCC2397 | Muristerone A |
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Ecdysone analog that acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells.
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| BCC2398 | SU 9516 |
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Potent, selective cdk2 inhibitor (IC<sub>50</sub> values are 0.022, 0.04, 0.2, >10, >10, 18 and >100 <span class='symbol'>μ</span>M for cdk2, cdk1, cdk4, PKC, p38, PDGFR and EGFR respectively). Inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G<sub>1</sub> and G<sub>2</sub>-M cell cycle arrest. Transcriptionally downregulates Mcl-1 and has antiproliferative, cytostatic and pro-apoptotic effects <em>in vitro</em>.
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| BCC2399 | Cesium chloride |
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Potassium channel blocker; inhibits the pacemaker current (I<sub>f</sub>) and the hyperpolarization-activated cationic current (I<sub>h</sub>). Prevents activation of caspase-3 and neuronal apoptosis in serum- and potassium-deprived cerebellar granule neurons by inactivating GSK-3<span class='symbol'>β</span>.
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| BCC2400 | DAPK Substrate Peptide |
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Synthetic peptide substrate for death associated protein kinase (DAPK) (K<sub>m</sub> = 9 <span class='symbol'>μ</span>M).
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