Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 297 - 304 of 9359 hot products
| Catalog No. | Product Name |
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| BCC2065 | YK-4-279 |
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Inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. Inhibits Ewing's sarcoma family tumor (ESFT) cell growth; induces apoptosis.
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| BCC2069 | Zardaverine |
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Phosphodiesterase inhibitor, selective for PDE3 and 4 (IC<sub>50</sub> values are 0.5 and 0.8 <span class='symbol'>μ</span>M respectively). Also available as part of the Phosphodiesterase Inhibitor.
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| BCC2072 | Ziprasidone hydrochloride monohydrate |
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Atypical antipsychotic that displays combined serotonin and dopamine receptor antagonism. Displays high affinity at 5-HT<sub>2A</sub> receptors with a 5-HT<sub>2A</sub>/D<sub>2</sub> affinity ratio greater than any other clinically available atypical antipsychotics (pK<sub>i</sub> values are 9.38, 8.88, 8.69, 8.47, 8.32, 8.14, 7.98, 7.49, 7.33 and 6.28 for 5-HT<sub>2A</sub>, 5-HT<sub>2C</sub>, 5-HT<sub>1D</sub>, 5-HT<sub>1A</sub>, D<sub>2</sub>, D<sub>3</sub>, <span class='symbol'>α</span><sub>1</sub>, D<sub>4</sub>, H<sub>1</sub> and D<sub>1</sub> receptors respectively).
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| BCC2080 | A-769662 |
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Potent, reversible AMP-activated protein kinase (AMPK) activator (EC<sub>50</sub> = 0.8 <span class='symbol'>μ</span>M) that displays selectivity towards <span class='symbol'>β</span>1 subunit-containing heterotrimers. Inhibits fatty acid synthesis (IC<sub>50</sub> = 3.2 <span class='symbol'>μ</span>M) and decreases plasma glucose and triglyceride levels <em>in vivo</em>. Also inhibits proliferation of mesenchymal stem cells, and impedes reprogramming of mouse embryonic fibroblasts to iPSCs.
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| BCC2084 | PF-03716556 |
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H<sup>+</sup>,K<sup>+</sup>-ATPase inhibitor (pIC<sub>50</sub> = 6 in human recombinant ion-leaky assays); more potent in acidic conditions. Highly selective for H<sup>+</sup>,K<sup>+</sup>-ATPase <em>in vitro</em>; displays no activity at Na<sup>+</sup>,K<sup>+</sup>-ATPase. Also displays selectivity for H<sup>+</sup>,K<sup>+</sup>-ATPase over a range of 50 receptors and ion channels (IC<sub>50</sub> > 10 <span class='symbol'>μ</span>M). Inhibits gastric acid secretion in rat and dog models.
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| BCC2086 | IU1 |
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Selective inhibitor of Usp14; inhibits the catalytic activity of proteasome-associated Usp14 <em>in vitro</em> (IC<sub>50</sub> < 4 <span class='symbol'>μ</span>M). Stimulates proteasome activity and substrate degradation.
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| BCC2087 | LDN 57444 |
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Inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity (K<sub>i</sub> = 0.4 <span class='symbol'>μ</span>M). Causes cell death through the apoptosis pathway; increases levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity. Activity leads to dramatic alterations in synaptic protein distribution and spine morphology <em>in vivo</em>.
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| BCC2088 | NSC 632839 hydrochloride |
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Inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC<sub>50</sub> values are 15.65 and 16.23 <span class='symbol'>μ</span>M in E1A and E1A/C9CN cells respectively).
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