Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 257 - 264 of 9359 hot products
| Catalog No. | Product Name |
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| BCC1905 | ROCK inhibitor |
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Potent and highly selective ROCK inhibitor (IC50 values are 0.6 and 1.1 nM for ROCK1 and ROCK2, respectively). Exhibits >200-fold selectivity over TRK and FLT3 receptors, and >900-fold selectivity over a panel of other kinases and cardiovascular relevent enzymes and receptors. Reduces blood pressure in normotensive and hypertensive rats. Orally active.
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| BCC1908 | Rotigotine hydrochloride |
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Dopamine D<sub>2</sub> and D<sub>3</sub> receptor agonist. K<sub>i</sub> values are 13 and 0.71 nM for D<sub>2</sub> and D<sub>3</sub> respectively. Also has significant affinity for 5-HT<sub>1A</sub> and adrenergic <span class='symbol'>α</span><sub>2B</sub> receptors. Exhibits antiparkinsonian acitivity.
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| BCC1910 | RS 504393 |
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Extremely selective CCR2 chemokine receptor antagonist (IC<sub>50</sub> values are 98 nM and > 100 <span class='symbol'>μ</span>M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC<sub>50</sub> = 330 nM) and ischemia-reperfusion injury in kidneys.
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| BCC1917 | Salinomycin sodium salt |
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Cytotoxic to breast cancer stem cells. Inhibits CD44 expression in breast cancer cells in vitro. Inhibits mammary tumor growth in mice. Also antibiotic.
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| BCC1918 | Salirasib |
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Inhibitor of active Ras proteins. Displaces active Ras from the plasma membrane; impairs downstream signaling and inhibits proliferation of endometrial carcinoma cells. Also facilitates Ras degradation. Shown to induce autophagy in several human cancer cell lines.
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| BCC1920 | Salmeterol xinafoate |
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Long-acting <span class='symbol'>β</span><sub>2</sub> adrenergic receptor agonist. Inhibits the release of histamine, leukotrienes and prostaglandin D<sub>2</sub>, and blocks GM-CSF production from human cultured mast cells. Exhibits efficacious bronchodilatory activity in patients with asthma or chronic obstructive pulmonary disease (COPD).
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| BCC1922 | Saquinavir mesylate |
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Inhibitor of human immunodeficiency virus (HIV) protease (Ki values are <0.1 and 0.12 nM for HIV-2 and HIV-1 protease respectively). Exhibits high antiviral activity and low cytotoxicity.
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| BCC1923 | SB 239063 |
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Potent and selective p38 MAP kinase inhibitor (IC<sub>50</sub> = 44 nM for p38<span class='symbol'>α</span>). Displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. Reduces inflammatory cytokine production and is neuroprotective following oral administration <em>in vivo</em>.
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