Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 153 - 160 of 9359 hot products
| Catalog No. | Product Name |
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| BCC1372 | ASP3026 |
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Potent anaplastic lymphoma kinase (ALK) inhibitor (IC50 = 3.5 nM). Also inhibits Ack and ROS1 activity (IC50 values are 5.8 and 8.9 nM respectively). Attenuates proliferation, and induces apoptosis of NPM-ALK+ T cell anaplastic large-cell lymphoma (ALCL) cells in vitro. Suppresses tumor growth of NPM-ALK+ ALCL cell xenografts in mice. Causes tumor shrinkage in hEML4-ALK transgenic mice. Orally available.
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| BCC1375 | Gossypolone |
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R-(-)-enantiomer of gossypol. Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis <em>in vitro</em> through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts <em>in vivo</em>.
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| BCC1389 | AZ20 |
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Potent and selective ATR kinase inhibitor (IC50 = 5 nM). Exhibits 7.6-fold selectivity over mTOR and selectivity over a panel of 442 kinases, including ATM kinase, PI3-K isoforms, and DNA-PK. Inhibits cell growth in cell lines with high baseline levels of replication stress. Displays antitumor effects in vivo.
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| BCC1397 | BAM7 |
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Bax activator (EC<sub>50</sub> = 3.3 <span class='symbol'>μ</span>M); binds at the BH3-binding site. Selective for Bax over other antiapoptotic and proapoptotic proteins. Triggers Bax oligomerization <em>in vitro</em>; induces Bax-mediated apoptosis in mouse embryonic fibroblasts.
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| BCC1412 | Bazedoxifene acetate |
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Potent selective estrogen receptor modulator (SERM) (IC<sub>50</sub> values are 26 and 99 nM for ER<span class='symbol'>α</span> and ER<span class='symbol'>β</span> respectively). Inhibits 17<span class='symbol'>β</span>-estradiol-induced proliferation in MCF-7 cells. Co-treatment with Raloxifene completely abolishes raloxifene-induced stimulation of luminal epithelial cells and myometrium.
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| BCC1417 | B-HT 920 |
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Dopamine D<sub>2</sub> receptor agonist, <span class='symbol'>α</span><sub>2</sub>-adrenoceptor agonist and 5-HT<sub>3</sub> receptor antagonist. Displays antiParkinsonian activity.
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| BCC1423 | BMS-345541 |
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Selective allosteric inhibitor of IKK (IC<sub>50</sub> values are 0.3 and 4.0 <span class='symbol'>μ</span>M for IKK<span class='symbol'>β</span> and IKK<span class='symbol'>α</span> respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production <em>in vitro</em> and blocks NF<span class='symbol'>κ</span>B dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis.
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| BCC1424 | BMS-509744 |
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Potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitor (IC50 = 19 nM). Displays 200-fold selectivity over Tec family kinases and 55-fold selectivity over other kinases tested. Reduces HIV infection of primary CD4+ T cells and attenuates the establishment of HIV infection in vitro. Reduces T cell proliferation and IL-2 production in vitro. Reduces lung inflammation in a mouse model of ovalbumin-induced allergy/asthma.
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