Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 129 - 136 of 9359 hot products
| Catalog No. | Product Name |
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| BCC1264 | Cabozantinib (XL184, BMS-907351) |
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Potent VEGFR inhibitor (IC50 = 0.035 nM); also inhibits c-Met, KIT, RET, FLT4, AXL, FLT3, FLT1 and Tie2 (IC50 values are 1.3, 4.6, 5.2, 6, 7, 11.3, 12 and 14.3 nM, respectively). Induces intratumoral hypoxia and apoptosis. Reduces tumor invasion and metastasis in vivo. Antiangiogenic.
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| BCC1275 | CHIR-99021 (CT99021) |
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Potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3) (IC<sub>50</sub> values are 6.7 and 10 nM for GSK-3β and GSK-3α respectively). Exhibits >500-fold selectivity for GSK-3 over closely related kinases; also displays >800-fold selectivity against 45 additional enzymes and receptors. In combination with ItemId=248590'>tranylcypromine</a> 3852), enables reprogramming of mouse embryonic fibroblasts, transduced by Oct4 and Klf4 only, into iPSCs. Enhances mouse and human ESC self-renewal when used in combination with PD 0325901.
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| BCC1277 | PD0325901 |
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Potent MEK1 and MEK2 inhibitor. Inhibits MEK activity in mouse colon 26 cells (IC50 = 0.33 nM). Inhibits the growth of melanoma cell lines in vitro and in vivo; induces G1-phase cell cycle arrest and apoptosis in a mouse xenograft model. Also inhibits production of proangiogenic cytokines such as VEGF. Enhances generation of induced pluripotent stem cells (iPSCs). Orally active.
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| BCC1284 | (R)-Crizotinib |
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Potent inhibitor of c-MET and anaplastic lymphoma kinase (ALK) (cell IC50 values are 8.0 and 20 nM respectively). Selective for c-MET and ALK against >120 different kinases. Displays antitumor efficacy in multiple tumor models; inhibits c-MET-dependent proliferation, migration and invasion of human tumor cells in vitro. Orally bioavailable.
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| BCC1287 | P005091 |
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Selective inhibitor of ubiquitin-specific protease (USP) 7 (IC<sub>50</sub> = 4.2 <span class='symbol'>μ</span>M). Displays little-to-no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases; exhibits some activity at USP47. Induces elevated p53 and apoptosis in cancer cell lines; displays antiangiogenic activity <em>in vivo</em>.
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| BCC1294 | (S)-Tedizolid |
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(S)-Tedizolid is the S-enantiomer of Tedizolid. Tedizolid is a novel oxazolidinone with activity against Gram-positive pathogens. (S)-Tedizolid is the less active isomer.
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| BCC1298 | 1alpha, 24, 25-Trihydroxy VD2 |
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1alpha, 24, 25-Trihydroxy VD2 is a vitamin D analog.
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| BCC1299 | 1alpha, 25-Dihydroxy VD2-D6 |
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1alpha, 25-Dihydroxy VD2-D6 is a deuterated form of vitamin D.
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