Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 113 - 120 of 9359 hot products
| Catalog No. | Product Name |
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| BCC1228 | Nafamostat Mesylate(FUT-175) |
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Broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.
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| BCC1229 | PMSF |
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Non-selective protease inhibitor; irreversibly sulfonates key active site serine residues in serine proteases, acetylcholinesterases, and thiol proteases. Blocks metabolism of anandamide in a rodent model of cannabimimetic activity. Unstable in water (t<sub>1/2</sub> ~ 60 mins at pH 7.5). Brain penetrant.
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| BCC1233 | Calpain Inhibitor I, ALLN |
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Calpain inhibitor (IC<sub>50</sub> = 0.09 <span class='symbol'>μ</span>M) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation <em>in vitro</em>. Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.
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| BCC1234 | Calpain Inhibitor II, ALLM |
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Very potent inhibitor of cathepsin L (Ki = 0.6 nM) and the strongest inhibitor of cathepsin B (Ki = 100 nM) amongst the peptide aldehydes. Also inhibits processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro.
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| BCC1239 | VU 0364439 |
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Positive allosteric modulator (PAM) of mGlu4 receptors (EC50 = 19.8 nM in vitro for human mGlu4).
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| BCC1243 | SU11274 |
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Selective inhibitor of MET tyrosine kinase activity (IC<sub>50</sub> = 0.01 <span class='symbol'>μ</span>M <em>in vitro</em>). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration <em>in vitro</em> and tumor angiogenesis <em>in vivo</em>.
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| BCC1244 | TGX-221 |
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Potent and selective PI 3-kinase <span class='symbol'>β</span> inhibitor (IC<sub>50</sub> values are 0.007, 0.1, 3.5 and 5 <span class='symbol'>μ</span>M for the <span class='symbol'>β</span>, <span class='symbol'>δ</span>, <span class='symbol'>γ</span> and <span class='symbol'>α</span> isoforms, respectively). Shows >1,000-fold selectively for PI 3-kinase <span class='symbol'>β</span> over a range of other kinases. Inhibits thrombus formation in animal models.
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| BCC1245 | 10Panx |
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Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X<sub>7</sub>-mediated dye uptake, ATP-mediated IL-1<span class='symbol'>β</span> release and caspase-1 activation without altering membrane current in macrophages <em>in vitro</em>. Also blocks activation of NMDA receptor secondary currents (I<sub>2nd</sub>) by > 70%.
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