Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN1845 | Nocamycin I |
| 1. Nocamycin I shows potent antimicrobial activity and it holds great potential for antibacterial agent design. | |
| BCN1846 | Antibiotic BU 2313A |
| 1. Antibiotic Bu-2313 A and Antibiotic Bu-2313 B each exhibit a broad antibiotic spectrum against Gram-positive and Gram-negative anaerobic bacteria, and show in vivo activity against experimental infections produced by B. fragilis and C. perfringens. | |
| BCN1848 | Oleficin |
| 1. Oleficin, a polyene antibiotic, it is active against Grampositive bacteria and has no effect upon the growth of fungi and yeasts. 2. Oleficin has effects on mitochondrial functions can be explained on the basis of an increase of the inner membrane permeability as the consequence of the depletion of Mg2+ from mitochondria caused by the antibiotic. 3. Oleficin could as an ionophore of Mg2+ in isolated rat liver mitochondria, preferentially inhibit growth of the yeast Saccharomyces cerevisiae on non-fermentable substrates. | |
| BCN1849 | Oteromycin |
| 1. Oteromycin is a inhibitor of HIV-1 integrase. | |
| BCN1850 | Antibiotic ZG 1494alpha |
| 1. Antibiotic ZG 1494alpha is a novel inhibitor of platelet-activating factor (PAF) acetyltransferase. 2. Antibiotic ZG-1494alpha exhibits antifungal activity against Candida albicans. | |
| BCN1853 | Pramanicin |
| 1. Pramanicin, an antifungal agent, has vasorelaxant effect, it induces a slow endothelium-dependent relaxation, which could be reversed with the NO synthase inhibitor, L-NOARG . 2. Pramanicin has potent, selective, and irreversible inhibitory effect on the endothelial , thus it has potential development into an anti-angiogenic drug. 3. Pramanicin causes an initial slow endothelium-dependent, NO-mediated vascular relaxation, followed by a cytotoxic effect on vascular endothelial cells, eventually resulting in the loss of vasorelaxant function. 4. Pramanicin as a potential apoptosis-inducing small molecule, which acts through a well-defined JNK- and p38-dependent apoptosis signalling pathway in Jurkat T leukemia cells. 5. Pramanicin is an antimicrobial agent . | |
| BCN1855 | Reutericyclin |
| 1. Reutericyclin is a unique antimicrobial tetramic acid produced by some strains of Lactobacillus reuteri. 2. Reutericyclin and nisin exhibit divergent effects on heat- and pressure-induced spore inactivation and membrane fluidity. 3. Dissipation of the membrane potential by active Reutericyclins correlated with inhibition of macromolecular synthesis in cells. 4. All reutericyclins can inhibit the growth of clinical isolates of drug-resistant Staphylococcus aureus, which exemplify the prospect of developing reutericyclins as new topical antibiotics. | |
| BCN1856 | Rubroside G |
| 1. Rubroside G may show antifungal activity against Aspergillus fumigatus and Candida albicans. | |
