Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 65 - 72 of 9359 hot products
| Catalog No. | Product Name |
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| BCC1132 | Bromodomain Inhibitor, (+)-JQ1 |
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Potent, high affinity, selective BET bromodomain inhibitor (IC<sub>50</sub> values are 17.7, 32.6, 76.9 and 12942 nM for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively; K<sub>d</sub> values are 49, 59.5, 82, 90.1, 128 and 190 nM for BRD4 (N), BRD3 (N), BRD3 (C), BRD4 (C), BRD2 (N) and BRDT (N) respectively). Induces squamous differentiation in NUT midline carcinoma (NMC) cell lines; inhibits tumor growth in NMC xenograft models <em>in vivo</em>. Exhibits reversible contraceptive effects in germ cells from male mice. Inactive analog (-)-JQ1 available.
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| BCC1133 | Lomeguatrib |
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Inhibitor of <em>O</em><sup>6</sup>-methylguanine-DNA methyltransferase (MGMT); (IC<sub>50</sub> = 0.009 <span class='symbol'>μ</span>M in cell-free extracts from HeLa S3 cells); attenuates MGMT activity <em>in vitro</em> and <em>in vivo</em>. Enhances the antitumor activity of temozolomide in both human melanoma and MCF-7 xenografts.
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| BCC1134 | RG 108 |
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Non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines <em>in vitro</em> without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes. Enhances the efficiency of induced pluripotent stem cell (iPS) generation.
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| BCC1136 | Zebularine |
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Orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC<sub>50</sub> = 120 <span class='symbol'>μ</span>M) and re-activates silenced genes in T24 bladder carcinoma cells. Inhibits cytidine deaminase (K<sub>i</sub> ~ 2 <span class='symbol'>μ</span>M); induces differentiation of mesenchymal stem cells into cardiomyocytes.
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| BCC1141 | CA 074 |
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Inhibitor of cathepsin B (K<sub>i</sub> = 2-5 nM). Displays selectivity over cathepsins H and L (K<sub>i</sub> = 40-200 <span class='symbol'>μ</span>M). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.
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| BCC1142 | Macitentan |
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Macitentan is an orally active, non-peptide dual endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
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| BCC1147 | BIBR 1532 |
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BIBR 1532 is a potent, selective and non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay.
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| BCC1149 | NSC 23766 |
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Selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC<sub>50</sub> ~ 50 <span class='symbol'>μ</span>M) without affecting Cdc42 or RhoA activation. Inhibits Rac1-mediated cell functions and is reported to reverse tumor cell phenotyes in prostate cancer cells.
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