Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 169 - 176 of 9359 hot products
| Catalog No. | Product Name |
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| BCC1481 | 1-(3,5-Di-tert-butyl-4-hydroxyphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)ethanone |
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Selectively inhibits protein kinase C (PKC)-induced activation of the NF-<span class='symbol'>κ</span>B pathway (IC<sub>50</sub> < 0.1 <span class='symbol'>μ</span>M for PMA</a>-stimulated IL-8 production). Inhibits antigen receptor-stimulated NF-<span class='symbol'>κ</span>B activation in chronic lymphocytic leukemia (CLL) B cells. Does not inhibit other NF-<span class='symbol'>κ</span>B pathways, including that activated by tumor necrosis factor (TNF).
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| BCC1486 | Clemizole hydrochloride |
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TRPC5 channel blocker (IC<sub>50</sub> values are 1.1, 6.4, 9.1, 11.3 and 26.5 <span class='symbol'>μ</span>M for TRPC5, TRPC4, TRPC3, TRPC6 and TRPC7 respectively). Exhibits minimal effect on TRPM3, TRPM8 and TRPV1-4 channels. Also histamine H<sub>1</sub> receptor antagonist and anticonvulsant in zebrafish Dravet syndrome model.
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| BCC1487 | Clozapine N-oxide (CNO) |
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Metabolite of clozapine. Activates human muscarinic designer receptors (DREADDs). Silences hippocampal neurons expressing hM<sub>4</sub> DREADDs <em>in vitro</em>. Suppresses food intake in hyperphagic mice with hM<sub>3</sub>Dq-expressing, LMO4-deficient, paraventricular hypothalamic neurons.
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| BCC1494 | Collagen proline hydroxylase inhibitor |
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Collagen proline hydroxylase inhibitor is a collagen proline hydroxylase inhibitor; useful for antifibroproliferative agents.
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| BCC1495 | Collagen proline hydroxylase inhibitor-1 |
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Collagen proline hydroxylase inhibitor-1 is an antifibroproliferative agents.
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| BCC1499 | CP-809101 hydrochloride |
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Potent and selective 5-HT2C receptor agonist (pEC50 values are 9.96, 7.19 and 6.81 for human 5-HT2C, 5-HT2B and 5-HT2A receptors respectively). Displays antipsychotic activity; suppresses condition avoidance responding (CAR) and inhibits PCP and amphetamine-stimulated hyperactivity in rats following subcutaneous administration.
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| BCC1501 | CPPHA |
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Positive allosteric modulator at mGlu1 and mGlu5; thought to act at a novel allosteric site. Potentiates mGlu5 responses by a mechanism distinct from that of VU 29.
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| BCC1503 | CVT-313 |
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cdk2 inhibitor (IC50 = 0.5 μM). Exhibits >8-fold selectivity for CDK2 over CDK1 and CDK4 (IC50 values are 4.2 and 215 μM, respectively). Inhibits proliferation rat neonatal aortic smooth muscle cells and a range of tumor cells lines in vitro. Inhibits restenosis in a rat carotid artery injury model.
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