Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN2113 | Petasitenine |
| 1. Petasitenine has toxicity, the toxic effect will be developed in the tissues other than the liver or in the species apart from rodents. 2. Petasitenine has carcinogenic activity. | |
| BCN2114 | Neopetasitenine |
| 1. Petasitenine and neopetasitenine show strong hepatotoxic activity. | |
| BCN2119 | Retrorsine |
| 1. Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. 2. OCT1 mediates the liver-specific uptake of Retrorsine, and plays an important role in Retrorsine-induced hepatotoxicity together with CYP3A4. Consequently, the OCT1 inhibitors could be applied to protect the liver from the toxicity of Retrorsine. | |
| BCN2120 | Isatidine |
| 1. Isatidine shows in vitro genotoxicity in Hep G2/SCGE assays. 2. Isatidine and sceleratine slightly raise blood pressure in cats following intravenous injection, and stimulate isolated guinea pigs' uteri. | |
| BCN2123 | Retusine |
| 1. Retusine has edema inhibition capacity, could be related to a reduction of the prostaglandin production. 2. Retusine shows activity against the Gram-positive bacteria C. diphtheria and S. aureus. | |
| BCN2124 | Rosmarinine |
| 1. The negative transformation response observed for the non-carcinogenic alkaloid Rosmarinine establishes that the carcinogenic alkaloids are inducing transformation rather than simply selecting for spontaneous transformants. 2. Rosmarinine shows toxic activity against neonate first instar larvae of the fall armyworm Spodoptera frugiperda (maize pest) when tested at 10, 50 and 100 ppm. | |
| BCN2127 | Senaetnine |
| 1. Senaetnine possesses mild alkylating reactivity, and the evidence indicates that it can cause moderate tissue injury without the need for metabolic activation. | |
| BCN2129 | Senecionine |
| 1. Senecionine (SEN) is a representative of the hepatotoxic pyrrolizidine alkaloids. | |
