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5,5'-Dimethoxylariciresinol 4-O-glucoside

CAS# 154418-16-3

5,5'-Dimethoxylariciresinol 4-O-glucoside

Catalog No. BCN1556----Order now to get a substantial discount!

Product Name & Size Price Stock
5,5'-Dimethoxylariciresinol 4-O-glucoside: 5mg $903 In Stock
5,5'-Dimethoxylariciresinol 4-O-glucoside: 10mg Please Inquire In Stock
5,5'-Dimethoxylariciresinol 4-O-glucoside: 20mg Please Inquire Please Inquire
5,5'-Dimethoxylariciresinol 4-O-glucoside: 50mg Please Inquire Please Inquire
5,5'-Dimethoxylariciresinol 4-O-glucoside: 100mg Please Inquire Please Inquire
5,5'-Dimethoxylariciresinol 4-O-glucoside: 200mg Please Inquire Please Inquire
5,5'-Dimethoxylariciresinol 4-O-glucoside: 500mg Please Inquire Please Inquire
5,5'-Dimethoxylariciresinol 4-O-glucoside: 1000mg Please Inquire Please Inquire

Quality Control of 5,5'-Dimethoxylariciresinol 4-O-glucoside

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Chemical structure

5,5'-Dimethoxylariciresinol 4-O-glucoside

3D structure

Chemical Properties of 5,5'-Dimethoxylariciresinol 4-O-glucoside

Cas No. 154418-16-3 SDF Download SDF
PubChem ID 91884978 Appearance Powder
Formula C28H38O13 M.Wt 582.6
Type of Compound Lignans Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S,3R,4S,5S,6R)-2-[4-[4-[(4-hydroxy-3,5-dimethoxyphenyl)methyl]-3-(hydroxymethyl)oxolan-2-yl]-2,6-dimethoxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
SMILES COC1=CC(=CC(=C1O)OC)CC2COC(C2CO)C3=CC(=C(C(=C3)OC)OC4C(C(C(C(O4)CO)O)O)O)OC
Standard InChIKey OSPNTYPNEPEMIS-PQDWNSJOSA-N
Standard InChI InChI=1S/C28H38O13/c1-35-17-6-13(7-18(36-2)22(17)31)5-15-12-39-26(16(15)10-29)14-8-19(37-3)27(20(9-14)38-4)41-28-25(34)24(33)23(32)21(11-30)40-28/h6-9,15-16,21,23-26,28-34H,5,10-12H2,1-4H3/t15?,16?,21-,23-,24+,25-,26?,28+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 5,5'-Dimethoxylariciresinol 4-O-glucoside

The herbs of Lonicera maackii

Biological Activity of 5,5'-Dimethoxylariciresinol 4-O-glucoside

Description1. 5,5'-Dimethoxylariciresinol-4'-O-beta-D-glucoside is shown to effectively enhance chemosensitivity of resistant cells, which makes it may be a suitable candidate for potential multidrug resistance (MDR)-reversing agents.

5,5'-Dimethoxylariciresinol 4-O-glucoside Dilution Calculator

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5,5'-Dimethoxylariciresinol 4-O-glucoside Molarity Calculator

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Preparing Stock Solutions of 5,5'-Dimethoxylariciresinol 4-O-glucoside

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7164 mL 8.5822 mL 17.1644 mL 34.3289 mL 42.9111 mL
5 mM 0.3433 mL 1.7164 mL 3.4329 mL 6.8658 mL 8.5822 mL
10 mM 0.1716 mL 0.8582 mL 1.7164 mL 3.4329 mL 4.2911 mL
50 mM 0.0343 mL 0.1716 mL 0.3433 mL 0.6866 mL 0.8582 mL
100 mM 0.0172 mL 0.0858 mL 0.1716 mL 0.3433 mL 0.4291 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 5,5'-Dimethoxylariciresinol 4-O-glucoside

Reversal of multidrug resistance by 5,5'-dimethoxylariciresinol-4-O-beta-D-glucoside in doxorubicin-resistant human leukemia K562/DOX.[Pubmed:24347768]

Indian J Pharmacol. 2013 Nov-Dec;45(6):597-602.

OBJECTIVE: The objective of this study was to investigate the reversal effects of 5,5'-dimethoxylariciresinol-4'-O-beta-D-glucoside (DMAG) extracted from traditional Chinese medicines Mahonia on multidrug resistance (MDR) of human leukemia cells to chemotherapeutic agents. MATERIALS AND METHODS: MTT(3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was performed to determine the effect of DMAG on doxorubicin sensitivity to K562/DOX cells. Propidium iodide /Hoechst 33342 double staining assay was used to investigate the effect of DMAG on doxorubicin-induced cellular apoptosis. Intracellular accumulation of doxorubicin and rhodamine 123 assay were performed to evaluate the effect of DMAG on drugs efflux activity of P-glycoprotein. RESULTS: DMAG significantly enhanced the doxorubicin cytotoxicity to K562/DOX cells. In the presence of 1.0 muM of DMAG, the IC50 of doxorubicin decreased from 34.93 +/- 1.37 muM to 12.51 +/- 1.28 muM. DMAG of 1.0 muM significantly enhanced doxorubicin-induced cell apoptosis in K562/DOX cells and the enhancement was time-dependent. A significant increase in accumulation of doxorubicin in the presence of DMAG was observed. After treatment of the K562/DOX cells for 1 h with 15.0 muM doxorubicin alone, the fluorescence intensity was 33093.12. With the addition of 1.0 muM of DMAG, the fluorescence intensity of doxorubicin was 2.3-fold higher. A significant increase of accumulation of rhodamine 123 in the presence of DMAG was also observed. With the addition of 1.0 muM of DMAG, the fluorescence intensity was increased by 49.11% compared with rhodamine 123 alone. CONCLUSION: DMAG was shown to effectively enhance chemosensitivity of resistant cells, which makes it might be a suitable candidate for potential MDR-reversing agents.

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