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D-(+)-Glucose

Naturally occurring monosaccharide CAS# 50-99-7

D-(+)-Glucose

Catalog No. BCN1259----Order now to get a substantial discount!

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Quality Control of D-(+)-Glucose

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Chemical structure

D-(+)-Glucose

3D structure

Chemical Properties of D-(+)-Glucose

Cas No. 50-99-7 SDF Download SDF
PubChem ID 107526 Appearance Powder
Formula C6H12O6 M.Wt 180.16
Type of Compound Miscellaneous Storage Desiccate at -20°C
Synonyms D-Glucose; Grape sugar; Glucopyranose;aldehydo-D-glucose
Solubility DMSO : 50 mg/mL (277.53 mM; Need ultrasonic)
H2O : ≥ 50 mg/mL (277.53 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal
SMILES C(C(C(C(C(C=O)O)O)O)O)O
Standard InChIKey GZCGUPFRVQAUEE-SLPGGIOYSA-N
Standard InChI InChI=1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h1,3-6,8-12H,2H2/t3-,4+,5+,6+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of D-(+)-Glucose

The leaves of Ginkgo biloba L.

Biological Activity of D-(+)-Glucose

DescriptionDextrose, a simple sugar (monosaccharide), is an important carbohydrate in biology, it exhibits marked antibacterial activity against Staphylococcus aureus,Escherichia coli and Pyocyanine. D-(+)-Glucose can prevent MPP+ toxicity, attenuate the loss of ATP, but do not reverse the complete inhibition of mitochondrial O2 consumption (MOC).
TargetsAntifection | ATP
In vivo

d-(+)-Glucose rescue against 1-methyl-4-phenylpyridinium toxicity through anaerobic glycolysis in neuroblastoma cells[Reference: WebLink]

Brain Research Volume 962, Issues 1–2, 7 February 2003, Pages 48–60

The active neurotoxin of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-phenylpyridinium (MPP+), exerts its lethal effect by inhibiting Complex I of the electron transport chain (ETC). MPP+ shuts down aerobic oxidative phosphorylation and ETC-mediated ATP synthesis.
METHODS AND RESULTS:
The present investigation examines anaerobic survival during MPP+ toxicity in murine neuroblastoma cells Neuro 2-A (N2-A). MPP+ addition to the cells resulted in a reduction in cell viability, mitochondrial O2 consumption (MOC) and ATP concentration in a dose-dependent manner. However, the addition of 10 mM of D-(+)-Glucose prevented MPP+ toxicity, attenuated the loss of ATP, but did not reverse the complete inhibition of MOC, indicating substrate level phosphorylation and explicit anaerobic survival. Glucose addition prevented MPP+-mediated drop in ΔΨm, endoplasmic reticulum and intracellular organelle membrane potential tantamount to an increase of cell viability. Secondly, we examined the metabolic regulation of pyruvate dehydrogenase (PDH) and carnitine palmitoyl transferase (CPT) activities during glucose rescue. These enzymes exert control over acetyl CoA reservoirs in the mitochondria during aerobic metabolism. dl-6,8-Thioctic acid (PDH prosthetic group) and insulin slightly augmented metabolic rate, resulting in enhanced vulnerability to MPP+ in a glucose-limited environment. Additional glucose prevented these effects. Amiodarone (CPT inhibitor) and glucagon did not hamper or potentiate glucose rescue against MPP+. These data support strict anaerobic glucose utilization in the presence of toxic levels of MPP+. Moreover, the findings indicate that MPP+ exerts two distinct modes of toxicity (fast and slow death). With MPP+ (<1 mM), anaerobic glycolysis is operational, and toxicity is strictly dependent upon glucose depletion. MPP+ (1–10 mM) initiated acute metabolic collapse, with failure to sustain or switch to anaerobic glycolysis.
CONCLUSIONS:
In conclusion, overcoming energy failure against MPP+ may involve targeting rate-limiting controls over anaerobic energy pathways.

Protocol of D-(+)-Glucose

Structure Identification
Tetrahedron,2000,11(23): 4701-8.

Synthesis of novel diphosphines from d-(+)-glucose. Use in asymmetric hydrogenation[Reference: WebLink]

A new family of bidentate diphosphine ligands which contain a glucofuranoside as a simple but highly effective chiral backbone are reported. These ligands are prepared in a few steps from readily available D-(+)-Glucose.
CONCLUSIONS:
These new ligands have been applied to the rhodium-catalysed hydrogenation of α,β–unsaturated carboxylic acid derivatives under very mild reaction conditions, with enantiomeric excesses of up to 98%.

Academic Forum of Nan Du, 2001.

Synthesis and Antibacterial Activity of Cu(Ⅱ) Complexes With D-(+)-Glucose Thiosemicarbazone[Reference: WebLink]


METHODS AND RESULTS:
Cu(C 7H 15 N 3O 5S)SO 4]solide complex has been synthesized by the reaction of D-(+)-Glucose thiosemicarbazone with copper sulfate.The formula and structure were confirmed by the chemical analysis,elemental analysis and IR spectrum.
CONCLUSIONS:
The complex exhibits marked antibacterial activity against Staphylococcus aureus,Escherichia coli and Pyocyanine.

D-(+)-Glucose Dilution Calculator

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D-(+)-Glucose Molarity Calculator

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Preparing Stock Solutions of D-(+)-Glucose

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.5506 mL 27.7531 mL 55.5062 mL 111.0124 mL 138.7655 mL
5 mM 1.1101 mL 5.5506 mL 11.1012 mL 22.2025 mL 27.7531 mL
10 mM 0.5551 mL 2.7753 mL 5.5506 mL 11.1012 mL 13.8766 mL
50 mM 0.111 mL 0.5551 mL 1.1101 mL 2.2202 mL 2.7753 mL
100 mM 0.0555 mL 0.2775 mL 0.5551 mL 1.1101 mL 1.3877 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on D-(+)-Glucose

Dextrose is the biologically active form of Glucose (D-Glucose).

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Description

Dextrose, a simple sugar (monosaccharide), is an important carbohydrate in biology.

Keywords:

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