Ganoderol BCAS# 104700-96-1 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 104700-96-1 | SDF | Download SDF |
| PubChem ID | 6439004 | Appearance | Powder |
| Formula | C30H48O2 | M.Wt | 440.7 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (3S,10S,13R,14R,17S)-17-[(E,2R)-7-hydroxy-6-methylhept-5-en-2-yl]-4,4,10,13,14-pentamethyl-2,3,5,6,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-3-ol | ||
| SMILES | CC(CCC=C(C)CO)C1CCC2(C1(CC=C3C2=CCC4C3(CCC(C4(C)C)O)C)C)C | ||
| Standard InChIKey | AOXXVRDKZLRGTJ-CUJMEZSJSA-N | ||
| Standard InChI | InChI=1S/C30H48O2/c1-20(19-31)9-8-10-21(2)22-13-17-30(7)24-11-12-25-27(3,4)26(32)15-16-28(25,5)23(24)14-18-29(22,30)6/h9,11,14,21-22,25-26,31-32H,8,10,12-13,15-19H2,1-7H3/b20-9+/t21-,22+,25?,26+,28-,29-,30+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Ganoderol B is a potent α-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of α-glucosidase is 119.8 uM. It may be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor. |
| Targets | Androgen Receptor |
| In vivo | The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum.[Pubmed: 17499997]Bioorg Med Chem. 2007 Jul 15;15(14):4966-72. Epub 2007 Apr 25.Ganoderol B with 5alpha-reductase inhibitory activity and the ability to bind to androgen receptor (AR) can inhibit androgen-induced LNCaP cell growth and suppress regrowth of the ventral prostate induced by testosterone in rats. The down-regulation of AR signaling by Ganoderol B provides an important mechanism for its anti-androgenic activity. In view of the fact that PSA (prostatic specific antigen, a well-accepted prognostic indicator of prostate cancer) is down-regulated, an important implication of this study is that Ganoderol B intervention strategy aimed at toning down the amplitude of androgen signaling could be helpful in controlling morbidity of prostate cancer. In conclusion, our result suggests that Ganoderol B might be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor. |
| Kinase Assay | Ganoderol B: a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum.[Pubmed: 21596546]Phytomedicine. 2011 Sep 15;18(12):1053-5.α-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates. The search for the constituents reducing α-glucosidase activity led to the finding of active compounds in the fruiting body of Ganoderma lucidum. The CHCl(3) extract of the fruiting body of G. lucidum was found to show inhibitory activity on α-glucosidase in vitro. The neutral fraction, with an IC(50) of 88.7 μg/ml, had stronger inhibition than a positive control, acarbose, with an IC(50) of 336.7 μg/ml (521.5 μM). The neutral fraction was subjected to silica gel column chromatography and repeated p-HPLC to provide an active compound, (3β,24E)-lanosta-7,9(11),24-trien-3,26-diol (Ganoderol B). It was found to have high α-glucosidase inhibition, with an IC(50) of 48.5 μg/ml (119.8 μM). |
Ganoderol B Dilution Calculator
Ganoderol B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2691 mL | 11.3456 mL | 22.6912 mL | 45.3823 mL | 56.7279 mL |
| 5 mM | 0.4538 mL | 2.2691 mL | 4.5382 mL | 9.0765 mL | 11.3456 mL |
| 10 mM | 0.2269 mL | 1.1346 mL | 2.2691 mL | 4.5382 mL | 5.6728 mL |
| 50 mM | 0.0454 mL | 0.2269 mL | 0.4538 mL | 0.9076 mL | 1.1346 mL |
| 100 mM | 0.0227 mL | 0.1135 mL | 0.2269 mL | 0.4538 mL | 0.5673 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Ganoderic acid K
Catalog No.:BCN3039
CAS No.:104700-95-0
- Lupiwighteone
Catalog No.:BCN4045
CAS No.:104691-86-3
- Iriflophenone 3-C-beta-D-glucopyranoside
Catalog No.:BCN1635
CAS No.:104669-02-5
- 7,3'-Di-O-methylorobol
Catalog No.:BCN6831
CAS No.:104668-88-4
- H-Ile-NH2.HCl
Catalog No.:BCC2962
CAS No.:10466-56-5
- Dexpramipexole
Catalog No.:BCC1527
CAS No.:104632-28-2
- Dexpramipexole dihydrochloride
Catalog No.:BCC1528
CAS No.:104632-27-1
- Pramipexole
Catalog No.:BCC4467
CAS No.:104632-26-0
- Pramipexole dihydrochloride
Catalog No.:BCN2181
CAS No.:104632-25-9
- CGS 15943
Catalog No.:BCC7157
CAS No.:104615-18-1
- Caffeic acid phenethyl ester
Catalog No.:BCN2695
CAS No.:104594-70-9
- p-Menthan-3-one
Catalog No.:BCN3850
CAS No.:10458-14-7
- Ganoderol A
Catalog No.:BCN5860
CAS No.:104700-97-2
- Ganoderal A
Catalog No.:BCN2451
CAS No.:104700-98-3
- Boc-D-Glu(OtBu)-OH
Catalog No.:BCC3395
CAS No.:104719-63-3
- 8-Phenyloctanol
Catalog No.:BCC8791
CAS No.:10472-97-6
- 6-O-α-Maltosyl-β-cyclodextrin
Catalog No.:BCC8075
CAS No.:104723-60-6
- Mayteine
Catalog No.:BCN3098
CAS No.:104736-05-2
- 4E-Deacetylchromolaenide 4'-O-acetate
Catalog No.:BCN7263
CAS No.:104736-09-6
- Ganoderic acid S
Catalog No.:BCN5861
CAS No.:104759-35-5
- Strontium chloride
Catalog No.:BCC7973
CAS No.:10476-85-4
- GSK2141795
Catalog No.:BCC5294
CAS No.:1047634-65-0
- GSK2141795 hydrochloride
Catalog No.:BCC5295
CAS No.:1047635-80-2
- Afuresertib
Catalog No.:BCC5502
CAS No.:1047644-62-1
The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum.[Pubmed:17499997]
Bioorg Med Chem. 2007 Jul 15;15(14):4966-72.
The anti-androgenic activity of the ethanol extract of the fruiting body of Ganoderma lucidum has been previously reported. Ganoderol B with 5alpha-reductase inhibitory activity and the ability to bind to androgen receptor (AR) can inhibit androgen-induced LNCaP cell growth and suppress regrowth of the ventral prostate induced by testosterone in rats. The down-regulation of AR signaling by Ganoderol B provides an important mechanism for its anti-androgenic activity. In view of the fact that PSA (prostatic specific antigen, a well-accepted prognostic indicator of prostate cancer) is down-regulated, an important implication of this study is that Ganoderol B intervention strategy aimed at toning down the amplitude of androgen signaling could be helpful in controlling morbidity of prostate cancer. In conclusion, our result suggests that Ganoderol B might be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor.
Ganoderol B: a potent alpha-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum.[Pubmed:21596546]
Phytomedicine. 2011 Sep 15;18(12):1053-5.
alpha-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates. The search for the constituents reducing alpha-glucosidase activity led to the finding of active compounds in the fruiting body of Ganoderma lucidum. The CHCl(3) extract of the fruiting body of G. lucidum was found to show inhibitory activity on alpha-glucosidase in vitro. The neutral fraction, with an IC(50) of 88.7 mug/ml, had stronger inhibition than a positive control, acarbose, with an IC(50) of 336.7 mug/ml (521.5 muM). The neutral fraction was subjected to silica gel column chromatography and repeated p-HPLC to provide an active compound, (3beta,24E)-lanosta-7,9(11),24-trien-3,26-diol (Ganoderol B). It was found to have high alpha-glucosidase inhibition, with an IC(50) of 48.5 mug/ml (119.8 muM).
