Ganoderal ACAS# 104700-98-3 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 104700-98-3 | SDF | Download SDF |
| PubChem ID | 13934282 | Appearance | White cryst. |
| Formula | C30H44O2 | M.Wt | 436.68 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (E,6R)-2-methyl-6-[(5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-3-oxo-1,2,5,6,12,15,16,17-octahydrocyclopenta[a]phenanthren-17-yl]hept-2-enal | ||
| SMILES | CC(CCC=C(C)C=O)C1CCC2(C1(CC=C3C2=CCC4C3(CCC(=O)C4(C)C)C)C)C | ||
| Standard InChIKey | RHNFCIPJKSUUES-SPFFTVLFSA-N | ||
| Standard InChI | InChI=1S/C30H44O2/c1-20(19-31)9-8-10-21(2)22-13-17-30(7)24-11-12-25-27(3,4)26(32)15-16-28(25,5)23(24)14-18-29(22,30)6/h9,11,14,19,21-22,25H,8,10,12-13,15-18H2,1-7H3/b20-9+/t21-,22-,25+,28-,29-,30+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | The oxygenated sterols( 26-oxygenosterols ganoderol A, ganoderol B, ganoderal A, and ganoderic acid Y) from G. lucidum can inhibit cholesterol biosynthesis via conversion of acetate or mevalonate as a precursor of cholesterol. |
| In vitro | Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors.[Pubmed: 16000773]Appl Environ Microbiol. 2005 Jul;71(7):3653-8.Ganoderma lucidum is a medicinal fungus belonging to the Polyporaceae family which has long been known in Japan as Reishi and has been used extensively in traditional Chinese medicine. |
Ganoderal A Dilution Calculator
Ganoderal A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.29 mL | 11.45 mL | 22.9001 mL | 45.8001 mL | 57.2502 mL |
| 5 mM | 0.458 mL | 2.29 mL | 4.58 mL | 9.16 mL | 11.45 mL |
| 10 mM | 0.229 mL | 1.145 mL | 2.29 mL | 4.58 mL | 5.725 mL |
| 50 mM | 0.0458 mL | 0.229 mL | 0.458 mL | 0.916 mL | 1.145 mL |
| 100 mM | 0.0229 mL | 0.1145 mL | 0.229 mL | 0.458 mL | 0.5725 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Ganoderol A
Catalog No.:BCN5860
CAS No.:104700-97-2
- Ganoderol B
Catalog No.:BCN5859
CAS No.:104700-96-1
- Ganoderic acid K
Catalog No.:BCN3039
CAS No.:104700-95-0
- Lupiwighteone
Catalog No.:BCN4045
CAS No.:104691-86-3
- Iriflophenone 3-C-beta-D-glucopyranoside
Catalog No.:BCN1635
CAS No.:104669-02-5
- 7,3'-Di-O-methylorobol
Catalog No.:BCN6831
CAS No.:104668-88-4
- H-Ile-NH2.HCl
Catalog No.:BCC2962
CAS No.:10466-56-5
- Dexpramipexole
Catalog No.:BCC1527
CAS No.:104632-28-2
- Dexpramipexole dihydrochloride
Catalog No.:BCC1528
CAS No.:104632-27-1
- Pramipexole
Catalog No.:BCC4467
CAS No.:104632-26-0
- Pramipexole dihydrochloride
Catalog No.:BCN2181
CAS No.:104632-25-9
- CGS 15943
Catalog No.:BCC7157
CAS No.:104615-18-1
- Boc-D-Glu(OtBu)-OH
Catalog No.:BCC3395
CAS No.:104719-63-3
- 8-Phenyloctanol
Catalog No.:BCC8791
CAS No.:10472-97-6
- 6-O-α-Maltosyl-β-cyclodextrin
Catalog No.:BCC8075
CAS No.:104723-60-6
- Mayteine
Catalog No.:BCN3098
CAS No.:104736-05-2
- 4E-Deacetylchromolaenide 4'-O-acetate
Catalog No.:BCN7263
CAS No.:104736-09-6
- Ganoderic acid S
Catalog No.:BCN5861
CAS No.:104759-35-5
- Strontium chloride
Catalog No.:BCC7973
CAS No.:10476-85-4
- GSK2141795
Catalog No.:BCC5294
CAS No.:1047634-65-0
- GSK2141795 hydrochloride
Catalog No.:BCC5295
CAS No.:1047635-80-2
- Afuresertib
Catalog No.:BCC5502
CAS No.:1047644-62-1
- Entacapone sodium salt
Catalog No.:BCC4107
CAS No.:1047659-02-8
- 3alpha-Akebonoic acid
Catalog No.:BCN5862
CAS No.:104777-61-9
Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors.[Pubmed:16000773]
Appl Environ Microbiol. 2005 Jul;71(7):3653-8.
Ganoderma lucidum is a medicinal fungus belonging to the Polyporaceae family which has long been known in Japan as Reishi and has been used extensively in traditional Chinese medicine. We report the isolation and identification of the 26-oxygenosterols ganoderol A, ganoderol B, Ganoderal A, and ganoderic acid Y and their biological effects on cholesterol synthesis in a human hepatic cell line in vitro. We also investigated the site of inhibition in the cholesterol synthesis pathway. We found that these oxygenated sterols from G. lucidum inhibited cholesterol biosynthesis via conversion of acetate or mevalonate as a precursor of cholesterol. By incorporation of 24,25-dihydro-[24,25-3H2]lanosterol and [3-3H]lathosterol in the presence of ganoderol A, we determined that the point of inhibition of cholesterol synthesis is between lanosterol and lathosterol. These results demonstrate that the lanosterol 14alpha-demethylase, which converts 24,25-dihydrolanosterol to cholesterol, can be inhibited by the 26-oxygenosterols from G. lucidum. These 26-oxygenosterols could lead to novel therapeutic agents that lower blood cholesterol.
