Home >> Research Area >>Natural Products>>Triterpenoids>> 3alpha-Akebonoic acid

3alpha-Akebonoic acid

CAS# 104777-61-9

3alpha-Akebonoic acid

2D Structure

Catalog No. BCN5862----Order now to get a substantial discount!

Product Name & Size Price Stock
3alpha-Akebonoic acid: 5mg $903 In Stock
3alpha-Akebonoic acid: 10mg Please Inquire In Stock
3alpha-Akebonoic acid: 20mg Please Inquire Please Inquire
3alpha-Akebonoic acid: 50mg Please Inquire Please Inquire
3alpha-Akebonoic acid: 100mg Please Inquire Please Inquire
3alpha-Akebonoic acid: 200mg Please Inquire Please Inquire
3alpha-Akebonoic acid: 500mg Please Inquire Please Inquire
3alpha-Akebonoic acid: 1000mg Please Inquire Please Inquire

Quality Control of 3alpha-Akebonoic acid

3D structure

Package In Stock

3alpha-Akebonoic acid

Number of papers citing our products

Chemical Properties of 3alpha-Akebonoic acid

Cas No. 104777-61-9 SDF Download SDF
PubChem ID 91895432 Appearance Powder
Formula C29H44O3 M.Wt 440.7
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (4aS,6aR,6aS,6bR,8aR,10R,12aR,14bS)-10-hydroxy-6a,6b,9,9,12a-pentamethyl-2-methylidene-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
SMILES CC1(C2CCC3(C(C2(CCC1O)C)CC=C4C3(CCC5(C4CC(=C)CC5)C(=O)O)C)C)C
Standard InChIKey XWVVPZWKCNXREE-WPLIZOQJSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 3alpha-Akebonoic acid

The herbs of Akebia trifoliata

Biological Activity of 3alpha-Akebonoic acid

Description1. 3α-Akebonoic acid shows interesting in vitro growth inhibitory activity against human tumor A549 and HeLa cell lines, it also shows significant in vitro α-glucosidase inhibitory activity. 2. 3α-Akebonoic acid can interfer with presenilin-1 (PS1)/ β-site APP-cleaving enzyme 1 (BACE1) interaction and reduces Aβ production, the chemical interference of PS1/BACE1 interaction is a promising strategy for Alzheimer’s disease therapeutics.
TargetsBeta Amyloid | BACE

3alpha-Akebonoic acid Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

3alpha-Akebonoic acid Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of 3alpha-Akebonoic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2691 mL 11.3456 mL 22.6912 mL 45.3823 mL 56.7279 mL
5 mM 0.4538 mL 2.2691 mL 4.5382 mL 9.0765 mL 11.3456 mL
10 mM 0.2269 mL 1.1346 mL 2.2691 mL 4.5382 mL 5.6728 mL
50 mM 0.0454 mL 0.2269 mL 0.4538 mL 0.9076 mL 1.1346 mL
100 mM 0.0227 mL 0.1135 mL 0.2269 mL 0.4538 mL 0.5673 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on 3alpha-Akebonoic acid

Bioactive 30-noroleanane triterpenes from the pericarps of Akebia trifoliata.[Pubmed:24714192]

Molecules. 2014 Apr 4;19(4):4301-12.

Two new 30-noroleanane triterpenes, 2alpha,3beta,20alpha-trihydroxy-30-norolean-12-en-28-oic acid (1), 2alpha,3beta-dihydroxy-23-oxo-30-norolean-12,20(29)-dien-28-oic acid (2), were isolated from the pericarps of Akebia trifoliata, together with four known ones, 3beta-akebonoic acid (3), 2alpha,3beta-dihydroxy-30-noroleana-12,20(29)-dien-28-oic acid (4), 3alpha-Akebonoic acid (5) and quinatic acid (6). Their structures were established on the basis of detailed spectroscopic analysis, and they were all isolated from the pericarps of A. trifoliata for the first time. Compounds 3-6 showed in vitro bacteriostatic activity against four assayed Gram-positive bacterial strains. In particular 3 showed antibacterial activity toward MRSA with a MIC value 25 mug/mL, which was more potent than kanamycin (MIC 125 mug/mL). No compounds showed antibacterial activity toward the three Gram-negative bacteria tested. Compounds 4 and 5 showed interesting in vitro growth inhibitory activity against human tumor A549 and HeLa cell lines, with IC50 values ranging from 8.8 and 5.6 muM, respectively. Compounds 1, 2, 5 and 6 were further revealed to show significant in vitro alpha-glucosidase inhibitory activity with IC50 values from 0.035 to 0.367 mM, which were more potent than the reference compound acarbose (IC50 0.409 mM).

Keywords:

3alpha-Akebonoic acid,104777-61-9,Natural Products, buy 3alpha-Akebonoic acid , 3alpha-Akebonoic acid supplier , purchase 3alpha-Akebonoic acid , 3alpha-Akebonoic acid cost , 3alpha-Akebonoic acid manufacturer , order 3alpha-Akebonoic acid , high purity 3alpha-Akebonoic acid

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: