Alpha-TerpineolCAS# 10482-56-1 |
- Terpineol
Catalog No.:BCN3595
CAS No.:98-55-5
Quality Control & MSDS
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| Cas No. | 10482-56-1 | SDF | Download SDF |
| PubChem ID | 443162 | Appearance | Oil |
| Formula | C10H18O | M.Wt | 154.25 |
| Type of Compound | Monoterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 2-[(1S)-4-methylcyclohex-3-en-1-yl]propan-2-ol | ||
| SMILES | CC1=CCC(CC1)C(C)(C)O | ||
| Standard InChIKey | WUOACPNHFRMFPN-SECBINFHSA-N | ||
| Standard InChI | InChI=1S/C10H18O/c1-8-4-6-9(7-5-8)10(2,3)11/h4,9,11H,5-7H2,1-3H3/t9-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Alpha-Terpineol has antitumour activity. it inhibits the growth of tumour cells through a mechanism that involves inhibition of the NF-kappaB pathway. 2. Alpha-Terpineol has anti-inflammatory property, it can suppress the production of inflammatory mediators in LPS-stimulated human macrophages by interfering with the NF-kB, p38 or ERK MAPK pathways. 3. Alpha-Terpineol has potent antimicrobial activity against MRSA and may have utility as an anti-MRSA cleansing agent for dental instruments and dental unit chairs. |
| Targets | TNF-α | NF-kB | IL Receptor | p38MAPK | ERK | Antifection |
Alpha-Terpineol Dilution Calculator
Alpha-Terpineol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.483 mL | 32.4149 mL | 64.8298 mL | 129.6596 mL | 162.0746 mL |
| 5 mM | 1.2966 mL | 6.483 mL | 12.966 mL | 25.9319 mL | 32.4149 mL |
| 10 mM | 0.6483 mL | 3.2415 mL | 6.483 mL | 12.966 mL | 16.2075 mL |
| 50 mM | 0.1297 mL | 0.6483 mL | 1.2966 mL | 2.5932 mL | 3.2415 mL |
| 100 mM | 0.0648 mL | 0.3241 mL | 0.6483 mL | 1.2966 mL | 1.6207 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Alpha terpineol: a potential anticancer agent which acts through suppressing NF-kappaB signalling.[Pubmed:20651334]
Anticancer Res. 2010 Jun;30(6):1911-9.
BACKGROUND: Alpha terpineol is a bioactive component of Salvia libanotica essential oil extract and has shown antitumour activity. MATERIALS AND METHODS: The cytotoxicity of alpha terpineol towards different tumour cell lines was evaluated in vitro. Mechanistic characterization was performed using analysis of drug activity in a cell line panel and drug-induced gene expression perturbation using the connectivity map approach. RESULTS: The small cell lung carcinoma was the cell line most sensitive to alpha terpineol. The results proposed alpha terpineol as an NF-kappaB inhibitor, which was confirmed by the observed dose-dependent inhibition of NF-kappaB translocation and activity using two NF-kappaB assays, and by the down-regulation of the expression of several NF-kappaB-related genes such as IL-1 beta and IL1R1. CONCLUSION: The results suggest that alpha terpineol inhibits the growth of tumour cells through a mechanism that involves inhibition of the NF-kappaB pathway.
Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1beta, IL-6 and IL-10 on human macrophages.[Pubmed:24947163]
Inflamm Res. 2014 Sep;63(9):769-78.
OBJECTIVE: Tea tree oil (TTO) is an essential oil with anti-inflammatory properties, steam distilled from the plant Melaleuca alternifolia. We investigated the immunomodulatory properties of TTO and its components (terpinen-4-ol and Alpha-Terpineol) using lipopolysaccharide (LPS)-stimulated macrophages. METHODS: The ability of TTO, terpinen-4-ol and Alpha-Terpineol to modulate the macrophage response to bacterial LPS stimulation was assessed by ELISA for tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6 and IL-10 cytokine production and by western blotting for the activation of nuclear factor kappa B (NF-kappaB) and p38 mitogen-activated protein kinase (MAPK) signaling, which are associated with the expression of pro-inflammatory cytokines. We used a human monocytic cell line (U937) differentiated into macrophages. RESULTS: LPS induced the production of all cytokines, and TTO and its components significantly reduced the production of IL-1beta, IL-6 and IL-10. The production of TNF-alpha was not affected by either TTO or its major components. The modulation of cytokine production was not mediated by changes in NF-kappaB or p38 MAPK activation. CONCLUSION: TTO, terpinen-4-ol and Alpha-Terpineol can suppress the production of inflammatory mediators in LPS-stimulated human macrophages; this inhibition was mediated by interfering with the NF-kB, p38 or ERK MAPK pathways.
