TaxcultineCAS# 153415-46-4 |
Quality Control & MSDS
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| Cas No. | 153415-46-4 | SDF | Download SDF |
| PubChem ID | 3081898 | Appearance | Powder |
| Formula | C44H53NO14 | M.Wt | 819.90 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CCCC(=O)NC(C1=CC=CC=C1)C(C(=O)OC2CC3(C(C4C(C(CC5C4(CO5)OC(=O)C)O)(C(=O)C(C(=C2C)C3(C)C)OC(=O)C)C)OC(=O)C6=CC=CC=C6)O)O | ||
| Standard InChIKey | SXPIMOCRRJUHJY-MNLIZOKASA-N | ||
| Standard InChI | InChI=1S/C44H53NO14/c1-8-15-31(49)45-33(26-16-11-9-12-17-26)34(50)40(53)57-28-21-44(54)38(58-39(52)27-18-13-10-14-19-27)36-42(7,29(48)20-30-43(36,22-55-30)59-25(4)47)37(51)35(56-24(3)46)32(23(28)2)41(44,5)6/h9-14,16-19,28-30,33-36,38,48,50,54H,8,15,20-22H2,1-7H3,(H,45,49)/t28-,29-,30+,33-,34+,35+,36-,38-,42+,43-,44+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The cell cultures of Taxus baccata.
| Description | 1. Taxcultine can actively promote tubulin assembly. |
Taxcultine Dilution Calculator
Taxcultine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.2197 mL | 6.0983 mL | 12.1966 mL | 24.3932 mL | 30.4915 mL |
| 5 mM | 0.2439 mL | 1.2197 mL | 2.4393 mL | 4.8786 mL | 6.0983 mL |
| 10 mM | 0.122 mL | 0.6098 mL | 1.2197 mL | 2.4393 mL | 3.0492 mL |
| 50 mM | 0.0244 mL | 0.122 mL | 0.2439 mL | 0.4879 mL | 0.6098 mL |
| 100 mM | 0.0122 mL | 0.061 mL | 0.122 mL | 0.2439 mL | 0.3049 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Isolation and semi-synthesis of a bioactive taxane from Taxus canadensis.[Pubmed:8835457]
Phytochemistry. 1996 Feb;41(3):803-5.
A minor bioactive taxane, isolated from the needles of Taxus canadensis and semi-synthesized, was shown to be Taxcultine.
New bioactive taxoids from cell cultures of Taxus baccata.[Pubmed:7908950]
J Nat Prod. 1994 Jan;57(1):116-22.
Four new taxoids were isolated from cell cultures of Taxus baccata. Their structures were elucidated by spectroscopic analyses. Two were the aglycones corresponding to previously isolated 7-O-xylosides of taxol C [1] and 10-deacetyltaxol C [2]. The third [3] had an N-methylated side-chain, while the fourth, named Taxcultine [4], contained an n-propyl group on the side-chain. All four compounds actively promoted tubulin assembly. Taxol C [1] showed potent and selective cytotoxicity in the NCI human cell line screen.
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