Epilepsy Research

Epilepsy is a group of neurological conditions consisting of recurrent, usually unprovoked epileptic seizures. Epileptic seizures have recently been defined as "a transient occurrence of signs and/or symptoms due to abnormal, excessive or synchronous neuronal activity in the brain". Epilepsy is one of the most common disorders of the brain, with one in 10 people suffering at least one seizure in their lifetime. There are over 40 different types of epilepsy, each of which presents with its own unique combination of seizure type, typical age of onset, EEG findings, treatment, and prognosis.

Epilepsy Research Products Targets

Products for Epilepsy Research - Page 2

  1. Cat.No. Product Name Information/Activity
  2. BCC4104 GlyH-101 GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM. GlyH-101 chemical structure
  3. BCC6711 NPPB NPPB is a blocker of the outwardly rectifying chloride channel (ORCC). NPPB chemical structure
  4. BCC5248 PPQ-102 PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC50 of ~90 nM. PPQ-102 chemical structure
  5. BCC6220 T16Ainh - A01 T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC). T16Ainh - A01 chemical structure
  6. BCC7391 Talniflumate 66898-62-2 Talniflumate chemical structure
  7. BCC7578 KM 11060 KM11060 is a novel corrector of the F508del-CFTR trafficking defect. KM 11060 chemical structure
  8. BCC7820 PG 01 PG01 is a potent CFTR Cl- channel potentiator. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K PG 01 chemical structure
  9. BCC7886 BTZO 1 BTZO-1 binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro. BTZO 1 chemical structure
  10. BCC6816 Chicago Sky Blue 6B 2610-05-1 Chicago Sky Blue 6B chemical structure
  11. BCC6161 (±)-CPSI 1306 (±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF). (±)-CPSI 1306 chemical structure

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