Nociception

Nociception is the sensory process that provides the signals that lead to pain. This occurs through nociceptors, primary sensory neurons that are activated by stimuli that cause tissue damage. Stimuli can include tissue injury, extremes of heat and noxious chemicals. Unlike other sensory neurons that detect vision or taste, nociceptors are located all around the body, particularly under the skin, however, they are notably absent from the brain.

Nociception Products Targets

Products for Nociception - Page 53

Cat.No. Product Name Information/Activity
BCN2571 L-Theanine L-Theanine (L-Glutamic Acid γ-ethyl amide）is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective and anti-oxidative activities. L-Theanine causes anti-stress effects via the inhibition of cortical neuron excitation by oral intake.
BCC2512 Zonisamide Zonisamide is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug.
BCC6746 L-Canavanine sulfate L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.
BCC2865 L-NAME hydrochloride L-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM.
BCC5674 7-NINA 161467-34-1
BCC6713 7-Nitroindazole 2942-42-9
BCC6788 L-NMMA acetate L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.
BCC2864 H-Arg(NO2)-OH 2149-70-4
BCC6847 TRIM 25371-96-4
BCC6566 cis-ACPD 477331-06-9