p53
The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.
Products for p53
- Cat.No. Product Name Information
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BCC1812
Nutlin-3a chiralMDM2 inhibitor, antiproliferative and antiproapoptotic
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BCC1895
RG7388MDM2 antagonist, oral, selective
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BCC2238
RITA (NSC 652287)p53-MDM2 interaction inhibitor; antitumor
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BCC2239
Tenovin-1Activates p53 transcriptional activity
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BCC2240
JNJ-26854165 (Serdemetan)P53 activator, blocking Mdm2-p53 interaction
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BCC2241
Pifithrin-α (PFTα)p53 inhibitor; supresses self renewal of embryonic stem cells
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BCC2242
NSC 319726Reactivator of mutant p53
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BCC2254
Nutlin-3MDM2 antagonist,inhibits MDM2-p53 interaction
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BCC2406
CP 31398 dihydrochloridep53-stabilizing agent
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BCC2407
Cyclic Pifithrin-α hydrobromidep53 inhibitor
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BCC2408
HLI 373Hdm2 inhibitor; activates p53-dependent transcription
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BCC2409
MIRA-1Restores mutant p53 activity; proapoptotic
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BCC2410
NSC 146109 hydrochlorideCell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription
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BCC2411
PhiKan 083p53 stabilizing agent
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BCC2412
Pifithrin-μInhibitor of p53-mitochondrial binding
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BCC2413
PRIMA-1Restores mutant p53 activity; induces apoptosis
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BCC2414
PRIMA-1METRestores mutant p53 activity
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BCC2415
RETRA hydrochlorideAntitumor agent
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BCC2416
SJ 172550MDMX inhibitor. Disrupts MDMX-p53 interaction
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BCC2417
WR 1065p53 activator. Also ROS scavenger
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BCC3889
Tenovin-3
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BCC3989
ONC201activates p53-independent apoptosis
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BCC3992
AMG232p53-MDM2 inhibitor, novel
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BCC5395
NVP-CGM097
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BCC6540
NSC59984Restores the p53 signaling pathway