Tenovin-3CAS# 1011301-27-1 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 1011301-27-1 | SDF | Download SDF |
| PubChem ID | 24772097 | Appearance | Powder |
| Formula | C18H21N3OS | M.Wt | 327.44 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 31 mg/mL (94.67 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamide | ||
| SMILES | CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)N | ||
| Standard InChIKey | NLAXTZPUTNGRDU-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C18H21N3OS/c1-18(2,3)13-6-4-12(5-7-13)16(22)21-17(23)20-15-10-8-14(19)9-11-15/h4-11H,19H2,1-3H3,(H2,20,21,22,23) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.
Target: p53
in vitro: Tenovins inhibit the activities of human SirT1 and SirT2, two members of the NAD+-dependent class III histone deacetylases that also belong to the sirtuin family.[1] References: | |||||
Tenovin-3 Dilution Calculator
Tenovin-3 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.054 mL | 15.27 mL | 30.5399 mL | 61.0799 mL | 76.3499 mL |
| 5 mM | 0.6108 mL | 3.054 mL | 6.108 mL | 12.216 mL | 15.27 mL |
| 10 mM | 0.3054 mL | 1.527 mL | 3.054 mL | 6.108 mL | 7.635 mL |
| 50 mM | 0.0611 mL | 0.3054 mL | 0.6108 mL | 1.2216 mL | 1.527 mL |
| 100 mM | 0.0305 mL | 0.1527 mL | 0.3054 mL | 0.6108 mL | 0.7635 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Tenovin SAR Studies Aimed at Increasing Water Solubility
| ID |  | p53 Increasea | K40Ac Tubulin Increaseb | SirT2 Inhibitionc | |
|---|---|---|---|---|---|
| R1 | R2 | ||||
| Tenovin-1 | tBu | NHCOCH3 | + | + | + |
| Tenovin-2 | tBu | NHCOCH(CH3)2 | + | + | + |
| Tenovin-3 | tBu | NH2 | + | + | + |
| Tenovin-4 | N3 | NHCOCH3 | − | − | − |
| Tenovin-5 | tBu | NHCOPh | + | + | + |
| Tenovin-6 | tBu | NHCO(CH2)4NMe2.HCl | + | + | + |
- a Ability to increase p53 levels was determined in MCF-7 cells treated for 6 hr at 10 μM.
- b Ability to increase K40 Ac-tubulin levels was determined in H1299 cells treated
- c SirT2 inhibition assessed using a compound concentration of 10 or 30 μM depending on the compound's solubility in the assay buffer.
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Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.
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