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BCN1550 |
3-O-(2'E ,4'Z-decadienoyl)-20-O-acetylingenol
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1. 3-O-(2′E,4′Z-decadienoyl)-20-O-acetylingenol, one toxic terpenoid from raw Gansui.
2. 3-O-(2′E,4′Z-decadienoyl)-20-O-acetylingenol has strong cytotoxicity against human normal cell lines L-O2 and GES-1 with dose-dependent relationships .
3. 20-O-acetyl-[3-O-(2'E,4'Z)-decadienoyl]-ingenol and 3-O-(2'E,4'Z)-decadienoylingenol show the same antinematodal activity against the nematode, Bursaphelenchus xylophilus, at a minimum effective dose (MED) of 5 microg/cotton ball.
4. 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol induces the cytotoxicity of intestinal epithelial cells of rats (IEC-6 cells) depends on induction of cell apoptosis via mitochondrial pathway and cell cycle arrest.
5. 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol, kansuinine B and kansuinine A can markedly promote SPL proliferation and NO production by PMphi at concentrations from 0.78 to 12.50 microg/mL, hence the they are believed to be important proinflammatory components of the roots of E. kansui. |
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BCN1638 |
2,3,23-Trihydroxy-12-oleanen-28-oic acid
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1. 2β,3β,23α-Trihydroxy-12-oleanen-28-oic acid shows cytotoxic activities to human lung adenocarcinoma(A-549)cell lines.
2. 2α,3β,23-Trihydroxyolean-12-en-28-oic acid and 2α,3β,23-trihydroxyurs-12-en-28-oic acid exhibit cytotoxicity in vitro against the growth of human cancer cells lines HepG-2,with IC50 values of 16.13 ± 3.83, 15.97 ± 2.47 uM, respectively. |
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BCN1658 |
3,5-Dihydroxyergosta-7,22-dien-6-one
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1. 3β,5α-Dihydroxy-(22E,24R)-ergosta-7,22-dien-6-one exhibits strong or moderate cytotoxic activities against MCF-7, A549, Hela and KB cell lines with IC50 values 4.98 (MCF-7), 1.95 (A549), 0.68(Hela), and 1.50 uM (KB), respectively. |
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BCN1672 |
Micromelin
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1. Micromelin exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100. |
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BCN1673 |
Phytol
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Phytol, a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive, antioxidant ,anti-inflammatory, antimicrobial, antileishmanial, cytotoxicity and antiallergic effects. It is a specific activator of PPARα, it interacts with GABAA receptor, probably at the receptor subtypes that mediate benzodiazepines effects. Phytol attenuates the inflammatory response by inhibiting neutrophil migration that is partly caused by reduction in IL-1β and TNF-α levels and oxidative stress. |
