Products with Cytotoxic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN1708 | Catalpalactone |
| 1. Catalpalactone can inhibit dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities and enhance L-DOPA- induced cytotoxiciy in PC12 cells. 2. Catalpalactone displays good cytotoxicity activities against two human tumor cell lines(MCF-7,BxPC3). 3. Catalpalactone exhibits significant inhibitory activity against 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells. 4. Catapalactone exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. 5. Catalpalactone exhibits high antitermitic activity. | |
| BCN1709 | Sambutoxin |
| 1. Sambutoxin, a new mycotoxin produced by toxic Fusarium isolates obtained from rotted potato tubers, it can cause toxic effects in rats, including body weight loss, feed refusal, hemorrhage in the stomach and intestines, and, finally, death when rats were fed diets supplemented with 0.05 and 0.1% sambutoxin. 2. Sambutoxin inhibits rabbit platelet aggregation, which may be party due to the decrease of ATP release. 3. Sambutoxin has in vitro cytotoxicity against various human and murine tumor cells and values of sambutoxin ranged from 46.2 to 1,425.6 ng/ml. | |
| BCN1712 | Villosin C |
| 1. Villosin C and villosin B have remarkable cytotoxic effects against four cancer cell lines (A549, HepG-2, MCF-7 and 4T1), with IC50 values ranging from 8.79 to 35.46 microM. | |
| BCN1717 | Lupenone |
| Lupenone and lupeol inhibit protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 13.7 ± 2.1 and 5.6 ± 0.9 uM, respectively, they are non−competitive inhibitors of PTP1B, and PTP1B appears to be an attractive target for the development of new drugs for type 2 diabetes and obesity. Lupenone stimulates melanogenesis by increasing the tyrosinase enzyme expression via mitogen-activated protein kinase phosphorylated extracellular signal-regulated kinases 1 and 2 phosphorylation inhibition. A 1 : 4 mixture of Lupenone and caryophyllene oxide shows trypanocidal activity. | |
| BCN1719 | Myriceric acid C |
| 1. Myriceric acid C has cytotoxic activity against human lung carcinoma and breast carcinoma. | |
