Products with Cytotoxic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2420 | Cyclo(Pro-Val) |
| Cyclo(Pro-Val) shows cyctoxic, moderate antifungal and weak antitumor activities in vitro, it can inhibit the growth of Bacillus subtilis with the minimal inhibitory concentration (MIC) value of 0.8 g/L. Cyclo(Pro-Val) and cyclo(Pro-Tyr) are toxic to both suspension cells and seedlings of Pinus thunbergii, which may offer some clues to research the mechanism of pine wilt disease caused by pine wood nematode. | |
| BCN2432 | Cyclo(Tyr-Leu) |
| Cyclo(Tyr-Leu) shows cytotoxicity, antifungal,and anticoagulant activities. | |
| BCN2434 | Cyclo(Ile-Leu) |
| Cyclo(Ile-Leu) shows cytotoxic activity in vitro. | |
| BCN2440 | Ganoderic acid Z |
| 1. Ganoderic acid zeta has cytotoxicity in vitro against Meth-A and LLC cell lines. 2. The binding affinities of ganoderic acid DM and Z (ΔGbind, −16.83 and−10.99 kcal mol−1) are comparable to that of current commercial drug oseltamivir (−23.62 kcal mol−1);Ganoderic acid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir, it has steric hindrance on the 150 cavity of N1 protein, and exerts activities across the H274Y and N294S mutations, is the attractive candidates of novel neuraminidase (NA) inhibitors. | |
| BCN2441 | Ganoderic acid AM1 |
| 1. Ganoderic acid AM1 treatment for 48 h inhibited the proliferation of HeLa human cervical carcinoma cells with IC(50) values of 19.8+/-0.7 microM. | |
