Marbofloxacin hydrochlorideCAS# 115551-26-3 |
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Quality Control & MSDS
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Chemical structure
3D structure
Cas No. | 115551-26-3 | SDF | Download SDF |
PubChem ID | 14576609 | Appearance | Powder |
Formula | C17H20ClFN4O4 | M.Wt | 398.82 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | Soluble in DMSO | ||
SMILES | CN1CCN(CC1)C2=C(C=C3C4=C2OCN(N4C=C(C3=O)C(=O)O)C)F.Cl | ||
Standard InChIKey | OCRYFLKYXNBUEY-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C17H19FN4O4.ClH/c1-19-3-5-21(6-4-19)14-12(18)7-10-13-16(14)26-9-20(2)22(13)8-11(15(10)23)17(24)25;/h7-8H,3-6,9H2,1-2H3,(H,24,25);1H | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Marbofloxacin hydrochloride is a potent antibiotic of which depends upon its inhibition of DNA-gyrase.
Target: DNA-gyrase
Marbofloxacin hydrochloride is a third-generation fluoroquinolone for veterinary use, the antimicrobial of which depends upon its inhibition of DNA-gyrase and topoisomerase IV. With a broad spectrum bactericidal activity and good efficacy, marbofloxacin hydrochloride is indicated for dermatological, respiratory and urinary tract infections due to both Gram-positive and Gram-negative bacteria and Mycoplasma [1].
Administration of Marbofloxacin hydrochloride at 6 mg/kg once daily for 7 days in a Staphylococcus aureus infection in tissue cages in ponies is not effective for the elimination of S. aureus infections from secluded sites [2]. The pharmacokinetic properties of marbofloxacin hydrochloride were investigated in 6 horses after i.v., subcutaneous and oral administration of a single dose of 2 mg/kg bwt and the minimal inhibitory concentrations (MIC) assessed for bacteria isolated from equine infectious pathologies. The clearance of marbofloxacin hydrochloride was mean +/- s.d. 0.25 +/- 0.05 l/kg/h and the terminal half-life 756 +/- 1.99 h. The marbofloxacin hydrochloride absolute bioavailabilities after subcutaneous and oral administration were 98 +/- 11% and 62 +/- 8%, respectively. Considering the breakpoint values of efficacy indices for fluoroquinolones, a marbofloxacin hydrochloride dosage regimen of 2 mg/kg bwt/24 h by i.v., subcutaneous or oral routes was more appropriate for enterobacteriaceae than for S. aureus [3].
Toxicity: cramps; vomiting; anorexia; soft stools; diarrhoea References: |
Marbofloxacin hydrochloride Dilution Calculator
Marbofloxacin hydrochloride Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.5074 mL | 12.537 mL | 25.074 mL | 50.1479 mL | 62.6849 mL |
5 mM | 0.5015 mL | 2.5074 mL | 5.0148 mL | 10.0296 mL | 12.537 mL |
10 mM | 0.2507 mL | 1.2537 mL | 2.5074 mL | 5.0148 mL | 6.2685 mL |
50 mM | 0.0501 mL | 0.2507 mL | 0.5015 mL | 1.003 mL | 1.2537 mL |
100 mM | 0.0251 mL | 0.1254 mL | 0.2507 mL | 0.5015 mL | 0.6268 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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Marbofloxacin hydrochloride is a potent antibiotic of which depends upon its inhibition of DNA-gyrase.
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