Tezampanel

AMPA and receptor antagonist CAS# 154652-83-2

Tezampanel

Catalog No. BCC1993----Order now to get a substantial discount!

Product Name & Size Price Stock
Tezampanel: 5mg $1645 In Stock
Tezampanel: 10mg Please Inquire In Stock
Tezampanel: 20mg Please Inquire Please Inquire
Tezampanel: 50mg Please Inquire Please Inquire
Tezampanel: 100mg Please Inquire Please Inquire
Tezampanel: 200mg Please Inquire Please Inquire
Tezampanel: 500mg Please Inquire Please Inquire
Tezampanel: 1000mg Please Inquire Please Inquire
Related Products
  • Ampalex

    Catalog No.:BCC1359
    CAS No.:154235-83-3
  • Noopept

    Catalog No.:BCC1804
    CAS No.:157115-85-0
  • LY450108

    Catalog No.:BCC1725
    CAS No.:376594-67-1
  • Perampanel

    Catalog No.:BCC1847
    CAS No.:380917-97-5
  • Aniracetam

    Catalog No.:BCC4219
    CAS No.:72432-10-1

Quality Control of Tezampanel

Number of papers citing our products

Chemical structure

Tezampanel

3D structure

Chemical Properties of Tezampanel

Cas No. 154652-83-2 SDF Download SDF
PubChem ID 127894 Appearance Powder
Formula C13H21N5O2 M.Wt 279.34
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in DMSO
Chemical Name (3S,4aR,6R,8aR)-6-[2-(2H-tetrazol-5-yl)ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid
SMILES C1CC2CNC(CC2CC1CCC3=NNN=N3)C(=O)O
Standard InChIKey ZXFRFPSZAKNPQQ-YTWAJWBKSA-N
Standard InChI InChI=1S/C13H21N5O2/c19-13(20)11-6-10-5-8(1-3-9(10)7-14-11)2-4-12-15-17-18-16-12/h8-11,14H,1-7H2,(H,19,20)(H,15,16,17,18)/t8-,9+,10-,11+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Tezampanel Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Tezampanel Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Tezampanel

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5799 mL 17.8993 mL 35.7987 mL 71.5973 mL 89.4967 mL
5 mM 0.716 mL 3.5799 mL 7.1597 mL 14.3195 mL 17.8993 mL
10 mM 0.358 mL 1.7899 mL 3.5799 mL 7.1597 mL 8.9497 mL
50 mM 0.0716 mL 0.358 mL 0.716 mL 1.4319 mL 1.7899 mL
100 mM 0.0358 mL 0.179 mL 0.358 mL 0.716 mL 0.895 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on Tezampanel

Tezampanel (LY293558) is a drug which acts as an antagonist at the AMPA and kainate families of ionotropic glutamate receptors, with selectivity for the GluR5 subtype of the kainate receptor. It has neuroprotective and anticonvulsant effects.

Featured Products
New Products
 

References on Tezampanel

Epidural tezampanel, an AMPA/kainate receptor antagonist, produces postoperative analgesia in rats.[Pubmed:17898404]

Anesth Analg. 2007 Oct;105(4):1152-9, table of contents.

BACKGROUND: We evaluated the epidural administration of Tezampanel, a non-N-methyl-d-aspartate receptor antagonist, in a rat model for postoperative pain. We sought to determine if this drug affects nociception when administered epidurally by testing its effects on responses to heat in normal rats. The effects of epidural Tezampanel on pain-related behaviors in rats that underwent plantar incision were also studied. METHODS: Rats were anesthetized and epidural catheters were placed. One day after epidural catheterization, the baseline heat withdrawal latency was measured. Epidural Tezampanel or morphine was tested for analgesia by examining their effects against heat withdrawal latency. Motor function was also tested. Comparisons to subcutaneous drug administration were made. Other rats underwent plantar incision after epidural catheterization to assess pain behavior caused by incision. The effects of epidural Tezampanel on the cumulative pain scoring, based on guarding, the withdrawal threshold to von Frey filament application, and the withdrawal latency to heat, were measured. The effects of epidural Tezampanel on arterial blood pressure and heart rate were also tested. RESULTS: Both epidural morphine and epidural Tezampanel increased withdrawal latency to heat. Only subcutaneous morphine affected heat withdrawal latency. After plantar incision, epidural Tezampanel decreased the median guarding pain score, increased the heat withdrawal latency and increased the mechanical withdrawal threshold indicating analgesic effects. Arterial blood pressure and heart rate did not change after epidural drug administration. CONCLUSION: These experiments demonstrate that epidural administration of Tezampanel produces analgesia to heat, motor side effects in some rats, and reduces pain behaviors caused by incision. No systemic analgesia was apparent using the largest dose.

Keywords:

Tezampanel,154652-83-2,Natural Products,AMPAR, buy Tezampanel , Tezampanel supplier , purchase Tezampanel , Tezampanel cost , Tezampanel manufacturer , order Tezampanel , high purity Tezampanel

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: