Depression Research

Major depressive disorder, often referred to as major depression, is a heterogenous condition with complex and diverse neurobiological etiologies. Depression is characterized by a triad of symptoms: low or depressed mood, anhedonia and low energy or fatigue. Approximately 15% of the population in developed countries has been affected by depression in their lifetime and the chance of developing depression is twice as high in women. 40-50% of depressive causes are inheritable (genes as yet unidentified) and the remaining 50-60% of causes are caused by environmental stressors.

Depression Research Products Targets

Products for Depression Research - Page 14

  1. Cat.No. Product Name Information/Activity
  2. BCC5063 BMY 7378 5-HT<sub>1A</sub> partial agonist,BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3. BMY 7378 chemical structure
  3. BCC4324 Carvedilol Carvedilol (BM 14190) is a non-selective β/α-1 blocker. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome. Carvedilol chemical structure
  4. BCC1257 Doxazosin Mesylate Doxazosin mesylate (UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. Doxazosin Mesylate chemical structure
  5. BCC6683 HEAT hydrochloride 30007-39-7 HEAT hydrochloride chemical structure
  6. BCC6688 Ifenprodil hemitartrate 23210-56-2 Ifenprodil hemitartrate chemical structure
  7. BCC6741 2-MPMDQ 149847-77-8 2-MPMDQ chemical structure
  8. BCC6726 2-PMDQ 139047-55-5 2-PMDQ chemical structure
  9. BCC2505 Prazosin HCl Prazosin hydrochloride is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder. Prazosin HCl chemical structure
  10. BCC7628 Rec 15/2615 dihydrochloride 173059-17-1 Rec 15/2615 dihydrochloride chemical structure
  11. BCC5741 RS 100329 hydrochloride 1215654-26-4 RS 100329 hydrochloride chemical structure

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