Epilepsy Research

Epilepsy is a group of neurological conditions consisting of recurrent, usually unprovoked epileptic seizures. Epileptic seizures have recently been defined as "a transient occurrence of signs and/or symptoms due to abnormal, excessive or synchronous neuronal activity in the brain". Epilepsy is one of the most common disorders of the brain, with one in 10 people suffering at least one seizure in their lifetime. There are over 40 different types of epilepsy, each of which presents with its own unique combination of seizure type, typical age of onset, EEG findings, treatment, and prognosis.

Epilepsy Research Products Targets

Products for Epilepsy Research - Page 18

  1. Cat.No. Product Name Information/Activity
  2. BCC7720 Indiplon 325715-02-4 Indiplon chemical structure
  3. BCC7009 Loreclezole hydrochloride Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. Loreclezole hydrochloride chemical structure
  4. BCC7984 MaxiPost Flindokalner (BMS-204352) is a potassium channel modulator. Flindokalner is a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is also a large conductance calcium-activated K channel (BKca) positive modulator. Flindokalner shows a negative modulatory activity at Kv7.1 channels (Ki=3.7 μM), and acts as a negative modulator of GABAA receptors. Flindokalner shows anxiolytic efficacy in vivo. MaxiPost chemical structure
  5. BCC6167 Ocinaplon 96604-21-6 Ocinaplon chemical structure
  6. BCC7470 Org 20599 156685-94-8 Org 20599 chemical structure
  7. BCC7452 17-PA 694438-95-4 17-PA chemical structure
  8. BCC7736 Pregnanolone 128-20-1 Pregnanolone chemical structure
  9. BCC4930 Primidone Primidone is an anticonvulsant of the pyrimidinedione class. Primidone chemical structure
  10. BCC7095 SB 205384 GABA<sub>A</sub> receptor modulator; slows current decay SB 205384 chemical structure
  11. BCC2314 Topiramate Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase. Topiramate chemical structure

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