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Proteasome

The proteasome is a large multisubunit complex of approximately 2.5 MDa that mediates a wide range of physiological and pathological cellular processes by selectively degrading unnecessary proteins in eukaryotes. The structure of a proteasome is comprised of the catalytic core particle (CP) and two terminal regulatory particles (RPs). The CP (also known as the 20S proteasome) is a barrel shaped multisubunit complex (approximately 750 kDa) consisting of four axially stacked heptameric rings (two outer α-rings and two inner β-rings) with 7 subunits in each ring, where three β subunits (β1, β2 and β5) contain catalytically active threonine residues and are associated with caspase-like, trypsin-like and chymotrypsin-like activities respectively.

Products for Proteasome

  1. Cat.No. Product Name Information
  2. BCN5973 Artemether
  3. BCN5986 Celastrol Topoisomerase II inhibitor
  4. BCN3894 Gliotoxin Inhibitor of 20S proteasome; immunosuppressant
  5. BCN1841 Lactacystin Cell-permeable, potent and selective proteasome inhibitor
  6. BCC1124 PSIProteasome inhibitor
  7. BCC1145 Carfilzomib (PR-171)Proteasome inhibitor,epoxomicin analog
  8. BCC1146 Oprozomib (ONX-0912)Proteasome inhibitor
  9. BCC1224 Clasto-Lactacystin β-lactoneProteasome inhibitor
  10. BCC1227 MG-132Calpain and proteasome inhibitor
  11. BCC1232 Aclacinomycin ATopoisomerase I and II inhibitor
  12. BCC1235 EpoxomicinProteasome inhibitor
  13. BCC1237 MG-115Potent reversible proteasome inhibitor
  14. BCC1238 Bortezomib (PS-341)Proteasome Inhibitor
  15. BCC2091 MLN9708Proteasome inhibitor
  16. BCC2092 MLN2238β5 site of the 20S proteasome inhibitor
  17. BCC2093 CEP-18770Proteasome inhibitor
  18. BCC2094 Salinosporamide A (NPI-0052, Marizomib)20S proteasome inhibitor
  19. BCC2095 ONX-0914 (PR-957)Immunoproteasome inhibitor,potent and selective
  20. BCC2097 Aspirin (Acetylsalicylic acid)Cyclooxygenase inhibitor; NSAID
  21. BCC3589 AM 11420S proteasome inhibitor
  22. BCC3596 DihydroeponemycinProteasome inhibitor,antitumor reagent,eponemycin ddrivative

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