Proteasome
The proteasome is a large multisubunit complex of approximately 2.5 MDa that mediates a wide range of physiological and pathological cellular processes by selectively degrading unnecessary proteins in eukaryotes. The structure of a proteasome is comprised of the catalytic core particle (CP) and two terminal regulatory particles (RPs). The CP (also known as the 20S proteasome) is a barrel shaped multisubunit complex (approximately 750 kDa) consisting of four axially stacked heptameric rings (two outer α-rings and two inner β-rings) with 7 subunits in each ring, where three β subunits (β1, β2 and β5) contain catalytically active threonine residues and are associated with caspase-like, trypsin-like and chymotrypsin-like activities respectively.
Products for Proteasome
- Cat.No. Product Name Information
- BCN5973 Artemether
- BCN5986 Celastrol Topoisomerase II inhibitor
- BCN3894 Gliotoxin Inhibitor of 20S proteasome; immunosuppressant
- BCN1841 Lactacystin Cell-permeable, potent and selective proteasome inhibitor
- BCC1124 PSIProteasome inhibitor
- BCC1145 Carfilzomib (PR-171)Proteasome inhibitor,epoxomicin analog
- BCC1146 Oprozomib (ONX-0912)Proteasome inhibitor
- BCC1224 Clasto-Lactacystin β-lactoneProteasome inhibitor
- BCC1227 MG-132Calpain and proteasome inhibitor
- BCC1232 Aclacinomycin ATopoisomerase I and II inhibitor
- BCC1235 EpoxomicinProteasome inhibitor
- BCC1237 MG-115Potent reversible proteasome inhibitor
- BCC1238 Bortezomib (PS-341)Proteasome Inhibitor
- BCC2091 MLN9708Proteasome inhibitor
- BCC2092 MLN2238β5 site of the 20S proteasome inhibitor
- BCC2093 CEP-18770Proteasome inhibitor
- BCC2094 Salinosporamide A (NPI-0052, Marizomib)20S proteasome inhibitor
- BCC2095 ONX-0914 (PR-957)Immunoproteasome inhibitor,potent and selective
- BCC2097 Aspirin (Acetylsalicylic acid)Cyclooxygenase inhibitor; NSAID
- BCC3589 AM 11420S proteasome inhibitor
- BCC3596 DihydroeponemycinProteasome inhibitor,antitumor reagent,eponemycin ddrivative