BCN5393CepharanthineCepharanthine, an alkaloid derived from Stephania cepharantha Hayata, with possesses anti-inflammatory and antioxidative activities. Cepharanthine attenuates muscle and kidney injuries induced by limb ischemia/reperfusion (I/R). Cepharanthine induces autophagy, apoptosis and cell cycle arrest in breast cancer cells. Cepharanthine inhibits the HIV-1 entry process by reducing plasma membrane fluidity.(CAS NO.:481-49-2)
BCN5575SarpagineBotanical source: The roots of Alstonia yunnanensis Diels(CAS NO.:482-68-8)
BCN5576AricineBotanical source: The herbs of Rauvolfia vomitoria Afzel.(CAS NO.:482-91-7)
BCN810914-DehydrobrowniineBotanical source: The roots of Delphinium stapeliosum(CAS NO.:4829-56-5)
BCN5577AjmalicineAjmalicine (Raubasine) is found in herbs of Catharanthus roseus, is an antihypertensive drug used in the treatment of high blood pressure, decreases peripheral resistance and blood pressure. Ajmalicine (Raubasine) is an adrenolytic drug which preferentially blocks alpha 1-adrenoceptor than alpha 2-adrenoceptor. Ajmalicine (Raubasine) is an reversible non-competitive nicotine receptor antagonist with an IC50 of 72.3 μM. Ajmalicine (Raubasine) acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2.(CAS NO.:483-04-5)
BCN5578IsorauhimbineBotanical source: The root of Rauvolfia serpentina(CAS NO.:483-09-0)
BCN2573DihydroberberineDihydroberberine inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces heat shock protein 90 (Hsp90) expression and its interaction with hERG. Dihydroberberine has anti-inflammatory, anti-atherosclerotic, hypolipidemic and antitumor activities.(CAS NO.:483-15-8)
BCC8143CephaelineCephaeline is a phenolic alkaloid in Indian Ipecac roots. Cephaeline exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections.(CAS NO.:483-17-0)
BCN2723(-)-IsocorypalmineBotanical source: The tubers of Corydalis yanhusuo W. T. Wang(CAS NO.:483-34-1)
BCN1273DictamnineDictamnine (Dictamine) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; A natural plant product has been reported to have antimicrobial activity against bacteria and fungi.(CAS NO.:484-29-7)
BCN7066IsodictamnineBotanical source: The roots of Dictamnus angustifolius G. Don.(CAS NO.:484-74-2)
BCN2460Brucine sulfateBotanical source: The seeds of Strychnos nux-vomica L.(CAS NO.:4845-99-2)
BCN4048N-NornuciferineN-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibits CYP2D6 with IC50 and Ki of 3.76 and 2.34 μM, respectively.(CAS NO.:4846-19-9)
BCN2658Aristolochic acid CAristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A2 (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis.(CAS NO.:4849-90-5)
BCN5583ReticulineReticuline, isolated from Litsea cubeba, shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3.(CAS NO.:485-19-8)
BCN6270CytisineCytisinicline (Cytisine) is an alkaloid that occurs naturally in several plant genera, such as Laburnum and Cytisus. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs, and partial to full agonist at β4 containing receptors and α7 receptors. Has been used medically to help with smoking cessation.(CAS NO.:485-35-8)
BCN1238(+)-Bicuculline(+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor.(CAS NO.:485-49-4)
BCN1792Choline sulphateBotanical source: The herbs of Abrus cantoniensis(CAS NO.:4858-96-2)
BCN5585(S)-CoclaurineCoclaurine is a class of tetrahydroisoquinoline alkaloids isolated from Sarcopetalum harveyanum. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist.(CAS NO.:486-39-5)
BCN3998HarmanBotanical source: The herbs of Rauvolfia verticillata(CAS NO.:486-84-0)
BCN1266N-MethylcytisineN-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia.(CAS NO.:486-86-2)
