BCN5273GardneramineBotanical source: The roots of Gardneria multiflora Makino(CAS NO.:34274-91-4)
BCN2485Harmine hydrochlorideHarmine Hydrochloride (Telepathine Hydrochloride) is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM.(CAS NO.:343-27-1)
BCN5275ChelerythrineChelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy.(CAS NO.:34316-15-9)
BCN3549IsovallesiachotamineBotanical source: The seeds of Strychnos nux-vomica Linn.(CAS NO.:34384-71-9)
BCN7362N-Demethyl-alpha-obscurineBotanical source: The whole plants of Lycopodium japonicum.(CAS NO.:34399-44-5)
BCN33038-AcetonyldihydroavicineBotanical source: The bark of Zanthoxylum tetraspermum(CAS NO.:348098-59-9)
BCN6320CoptisineCoptisine is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM.(CAS NO.:3486-66-6)
BCN5285PalmatinePalmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment.(CAS NO.:3486-67-7)
BCN5286VineridineBotanical source: The herbs of Vinca erecta(CAS NO.:3489-06-3)
BCN1767Obscuraminol CBotanical source: The Pseudodistoma obscurum(CAS NO.:350484-95-6)
BCN1770Obscuraminol DBotanical source: The Pseudodistoma obscurum(CAS NO.:350484-99-0)
BCN1769Obscuraminol EBotanical source: The Pseudodistoma obscurum(CAS NO.:350485-00-6)
BCN1768Obscuraminol FBotanical source: The Pseudodistoma obscurum(CAS NO.:350485-01-7)
BCN1766Obscuraminol BBotanical source: The Pseudodistoma obscurum(CAS NO.:350485-82-4)
BCN2334D-TetrahydropalmatineD-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis. D-Tetrahydropalmatine is a Dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors. D-Tetrahydropalmatine is a potent organic cation transporter 1 (OCT1) inhibitor.(CAS NO.:3520-14-7)
BCN2097Monocrotaline N-oxideMonocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo.(CAS NO.:35337-98-5)
BCN2756HirsuteineHirsuteine is an indole alkaloid extracted from Uncaria genus. Hirsuteine non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes.(CAS NO.:35467-43-7)
BCN2390BrucineBotanical source: The seeds of Strychnos nux-vomica L.(CAS NO.:357-57-3)
BCN2868GalantamineGalanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.(CAS NO.:357-70-0)