GSK2190915 sodium saltCAS# 1196070-26-4 |
- PP242
Catalog No.:BCC3682
CAS No.:1092351-67-1
- A66
Catalog No.:BCC3715
CAS No.:1166227-08-2
- CAL-101 (Idelalisib, GS-1101)
Catalog No.:BCC1270
CAS No.:870281-82-6
- PIK-294
Catalog No.:BCC4995
CAS No.:900185-02-6
- OSI-027
Catalog No.:BCC4603
CAS No.:936890-98-1
- KU-0063794
Catalog No.:BCC2484
CAS No.:938440-64-3
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 1196070-26-4 | SDF | Download SDF |
PubChem ID | 44473150 | Appearance | Powder |
Formula | C38H42N3NaO4S | M.Wt | 659.81 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Synonyms | GSK-2190915A; Fiboflapon sodium; AM-803 sodium | ||
Solubility | DMSO : ≥ 32 mg/mL (48.50 mM) *"≥" means soluble, but saturation unknown. | ||
Chemical Name | sodium;3-[3-tert-butylsulfanyl-1-[[4-(6-ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoate | ||
SMILES | CCOC1=NC=C(C=C1)C2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OCC5=NC=C(C=C5)C)C(=C3CC(C)(C)C(=O)[O-])SC(C)(C)C.[Na+] | ||
Standard InChIKey | NOJNFULGOQGBKB-UHFFFAOYSA-M | ||
Standard InChI | InChI=1S/C38H43N3O4S.Na/c1-8-44-34-18-14-28(22-40-34)27-12-10-26(11-13-27)23-41-32-17-16-30(45-24-29-15-9-25(2)21-39-29)19-31(32)35(46-37(3,4)5)33(41)20-38(6,7)36(42)43;/h9-19,21-22H,8,20,23-24H2,1-7H3,(H,42,43);/q;+1/p-1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
GSK2190915 sodium salt Dilution Calculator
GSK2190915 sodium salt Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 1.5156 mL | 7.5779 mL | 15.1559 mL | 30.3118 mL | 37.8897 mL |
5 mM | 0.3031 mL | 1.5156 mL | 3.0312 mL | 6.0624 mL | 7.5779 mL |
10 mM | 0.1516 mL | 0.7578 mL | 1.5156 mL | 3.0312 mL | 3.789 mL |
50 mM | 0.0303 mL | 0.1516 mL | 0.3031 mL | 0.6062 mL | 0.7578 mL |
100 mM | 0.0152 mL | 0.0758 mL | 0.1516 mL | 0.3031 mL | 0.3789 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
GSK2190915(AM-803; Fiboflapon) sodium salt is a potent FLAP(5-Lipoxygenase-activating protein) inhibitor with binding IC50 of 2.9 nM. IC50 value: 76 nM (inhibition of LTB4 in human blood 5 h incubation) [1] Target: FLAP inhibitor GSK2190915 exhibits excellent preclinical toxicology and pharmacokinetics in rat and dog. GSK2190915 also demonstrated an extended pharmacodynamic effect in a rodent bronchoalveolar lavage (BAL) model [1]. Oral administration of AM803 (1 mg/kg) resulted in sustained inhibition of ex vivo ionophore-challenged whole blood LTB4 biosynthesis with >90% inhibition for up to 12 h and an EC50 of approximately 7 nM. When rat lungs were challenged in vivo with calcium-ionophore, AM803 inhibited LTB4 and cysteinyl leukotriene (CysLT) production with ED50s of 0.12 mg/kg and 0.37 mg/kg, respectively. The inhibition measured 16 h following a single oral dose of 3 mg/kg was 86% and 41% for LTB4 and CysLTs, respectively. In an acute inflammation setting, AM803 dose-dependently reduced LTB4, CysLTs, plasma protein extravasation and neutrophil influx induced by peritoneal zymosan injection. Finally, AM803 increased survival time in mice exposed to a lethal intravenous injection of platelet activating factor (PAF) [2].
References:
[1]. Stock NS, et al. 5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once
[2]. Lorrain DS, et al. Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation. Eur J Pharmacol. 2010 Aug 25;640(1-3):211-8.
- 2-Hydroxyquinoxaline
Catalog No.:BCC8577
CAS No.:1196-57-2
- 7-Ethyl-10-Hydroxy-Camptothecin
Catalog No.:BCN8386
CAS No.:119577-28-5
- Dabrafenib Mesylate (GSK-2118436)
Catalog No.:BCC1513
CAS No.:1195768-06-9
- Dabrafenib (GSK2118436)
Catalog No.:BCC4393
CAS No.:1195765-45-7
- 11-Hydroxygelsenicine
Catalog No.:BCN4761
CAS No.:1195760-68-9
- N,N-Dimethylsphingosine
Catalog No.:BCC7959
CAS No.:119567-63-4
- Othonnine
Catalog No.:BCN2061
CAS No.:119565-25-2
- Ceanothic acid acetate
Catalog No.:BCN6083
CAS No.:119533-63-0
- Ethyllucidone
Catalog No.:BCN6082
CAS No.:1195233-59-0
- Meropenem trihydrate
Catalog No.:BCC4226
CAS No.:119478-56-7
- Fruquintinib(HMPL-013)
Catalog No.:BCC6415
CAS No.:1194506-26-7
- Eliprodil
Catalog No.:BCC7280
CAS No.:119431-25-3
- PF-3845
Catalog No.:BCC2326
CAS No.:1196109-52-0
- Olprinone Hydrochloride
Catalog No.:BCC1821
CAS No.:119615-63-3
- Sulfo-NHS-Biotin
Catalog No.:BCC3576
CAS No.:119616-38-5
- Arecaidine but-2-ynyl ester tosylate
Catalog No.:BCC6627
CAS No.:119630-77-2
- Naloxone benzoylhydrazone
Catalog No.:BCC5757
CAS No.:119630-94-3
- Moguisteine
Catalog No.:BCC4925
CAS No.:119637-67-1
- Yucalexin P-17
Catalog No.:BCN6595
CAS No.:119642-82-9
- Amadacycline methanesulfonate
Catalog No.:BCC1356
CAS No.:1196800-40-4
- 3',4'-Dihydroxyacetophenone
Catalog No.:BCN4775
CAS No.:1197-09-7
- Tranexamic acid
Catalog No.:BCN2710
CAS No.:1197-18-8
- 4-Aminophenylacetic acid
Catalog No.:BCC8687
CAS No.:1197-55-3
- 5-Methylfurmethiodide
Catalog No.:BCC6707
CAS No.:1197-60-0