Depression Research

Major depressive disorder, often referred to as major depression, is a heterogenous condition with complex and diverse neurobiological etiologies. Depression is characterized by a triad of symptoms: low or depressed mood, anhedonia and low energy or fatigue. Approximately 15% of the population in developed countries has been affected by depression in their lifetime and the chance of developing depression is twice as high in women. 40-50% of depressive causes are inheritable (genes as yet unidentified) and the remaining 50-60% of causes are caused by environmental stressors.

Depression Research Products Targets

Products for Depression Research - Page 4

  1. Cat.No. Product Name Information/Activity
  2. BCC6287 ANA 12 ANA-12 is a potent and selective TrkB antagonist with IC50s of 45.6 nM and 41.1 μM for the high and low affinity sites, respectively. ANA 12 chemical structure
  3. BCC6357 Cyclotraxin B 1203586-72-4 Cyclotraxin B chemical structure
  4. BCC4514 Tyrphostin AG 879 Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC50 of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity. Tyrphostin AG 879 chemical structure
  5. BCC3668 GNF-5837 GNF-5837 is a potent, selective, and orally bioavailable pan-tropomyosin receptor kinase (TRK) inhibitor which display antiproliferative effects in cellular Ba/F3 assays ( IC50 values of 7 nM, 9 nM and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively) . GNF-5837 chemical structure
  6. BCC5093 GW441756 GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM; little activity to c-Raf1 and CDK2. GW441756 chemical structure
  7. BCC7189 Demethylasterriquinone B1 78860-34-1 Demethylasterriquinone B1 chemical structure
  8. BCC5872 NTR 368 197230-90-3 NTR 368 chemical structure
  9. BCC7307 Ro 08-2750 Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 µM. Ro 08-2750 inhibits NGF binding to p75NTR selectively over TRKA. Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM. Ro 08-2750 chemical structure
  10. BCC2405 TLQP 21 869988-94-3 TLQP 21 chemical structure
  11. BCC1525 Desmopressin Synthetic vasopressin analog; V<sub>1B</sub> and V<sub>2</sub> agonist,Desmopressin(DDAVP) is the synthetic analogue of the antidiuretic hormone arginine vasopressin. Desmopressin chemical structure

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