BCN7439HydrangetinBotanical source: The rhizomes of Daphne papyracea var. crassiuscula.(CAS NO.:485-90-5)
BCN2327IsofraxidinIsofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation.(CAS NO.:486-21-5)
BCN5584FraxinolFraxinol is isolated from Lobelia chinensis.(CAS NO.:486-28-2)
BCN1051DaphnetinDaphnetin (7,8-dihydroxycoumarin), one coumarin derivative isolated from plants of the Genus Daphne, is a protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin (7,8-dihydroxycoumarin) is a secondary metabolite of plants used in folk medicine to counter inflammatory and allergic diseases, also has has the potential in the treatment of coagulation disorders, rheumatoid arthritis with anti-malarian and anti-pyretic properties.(CAS NO.:486-35-1)
BCN5588BergaptolBergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM.(CAS NO.:486-60-2)
BCN4831CitroptenCitropten (5,7-Dimethoxycoumarin) is a coumarin isolated from bergamot oil. Citropten (5,7-Dimethoxycoumarin) has an antiproliferative activity against A2058 human melanoma cell line.(CAS NO.:487-06-9)
BCN5603AurapteneAuraptene is the most abundant naturally occurring geranyloxycoumarin. Auraptene is primarily isolated from plants in the Rutaceae family, such as citrus fruits. Auraptene decreases the secretion of matrix metalloproteinase 2 (MMP-2) as well as key inflammatory mediators, including IL-6, IL-8, and chemokine (C-C motif) ligand-5(CCL5).(CAS NO.:495-02-3)
BCN3617AmmijinBotanical source: The herbs of Ammi majus(CAS NO.:495-30-7)
BCN2378NodakeninNodakenin is a major coumarin glucoside in the root of Peucedanum decursivum Maxim. Nodakenin inhibits acetylcholinesterase (AChE) activity with an IC50 of 84.7 μM.(CAS NO.:495-31-8)
BCN5604NodakenetinNodakenetin, isolated from Angelica decursiva, possesses antioxidant anti-inflammatory activities. Nodakenetin has the potential to be an antiarthritic and nerve tonic.(CAS NO.:495-32-9)
BCN7665(-)-Praeruptorin BBotanical source: The roots of Peucedanum praeruptorum Dunn.(CAS NO.:4970-26-7)
BCN7684ErythrocentaurinBotanical source: The whole plants of air-dried Swertia patens.(CAS NO.:50276-98-7)
BCN1275ColumbianadinColumbianadin, a natural coumarin from, is known to have various biological activities including anti-inflammatory and anti-cancer effects.(CAS NO.:5058-13-9)
BCN5641Murrangatin diacetateBotanical source: The herbs of Murraya exotica L.(CAS NO.:51650-59-0)
BCN5669AngelicinAngelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity.(CAS NO.:523-50-2)
BCN5672WedelolactoneWedelolactone, a natural product from Ecliptae herba, suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex. Wedelolactone inhibits 5-lipoxygenase (5-Lox) (IC50~2.5 μM) activity by an oxygen radical scavenging mechanism. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Anti-cancer, anti-inflammatory, and antioxidant activities.(CAS NO.:524-12-9)
BCN1237FraxinFraxin isolated from Acer tegmentosum, F. ornus or A. hippocastanum, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action, anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme.(CAS NO.:524-30-1)
BCN5675FraxidinFraxidin is a class of coumarin isolated from the roots of Jatropha podagrica, exhibits antibacterial activity against Bacillus subtilis with an inhibition zone of 12 mm at a concentration of 20 µg/disk.(CAS NO.:525-21-3)
BCC82876,7-Dihydroxy-4-Methylcoumarin4-Methylesculetin is an orally active natural coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity and reduces IL-6 level.(CAS NO.:529-84-0)
BCN5696MurralonginBotanical source: The herbs of Murraya exotica L.(CAS NO.:53011-72-6)
BCN5701ScopolinScopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots. Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades.(CAS NO.:531-44-2)
BCN27077-MethoxycoumarinHerniarin is a natural coumarin occurs in some flowering plants, with antitumor effect.(CAS NO.:531-59-9)
BCN5904EsculinEsculin, a fluorescent coumarin glucoside, is an active ingredient of ash bark. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti‑oxidative stress and anti‑inflammatory effects, via the MAPK signaling pathway.(CAS NO.:531-75-9)
BCN5704IsogosferolBotanical source: The roots of Heracleum repula(CAS NO.:53319-52-1)
