Adenosine Receptor - GPCR/G protein

Cat.No. Product Name Information

BCC6649 DPCPX DPCPX

BCC7599 PSB 0788

BCC7716 (±)-5'-Chloro-5'-deoxy-ENBA Highly selective A1 agonist

BCC7157 CGS 15943 CGS 15943 is an orally bioavailable non-xanthine Adenosine Receptor antagonist. Its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. .

BCC6165 TC-G 1004

BCC7598 PSB 603 PSB 603

BCC7338 CGH 2466 dihydrochloride Anti-inflammatory agent. Inhibitor of PDE4 and p38 MAPK, also adenosine receptor antagonist

BCC1475 CGS 21680 CGS 21680 is a selective adenosine A2A receptor agonist, with a Ki of 27 nM.

BCC4316 CGS 21680 HCl CGS 21680 Hydrochloride is a selective adenosine A2A receptor agonist with a Ki of 27 nM.

BCC7215 GR 79236 GR79236 is a highly potent and selective adenosine A1 receptor agonist (Ki = 3.1 nM) that has analgesic and anti-inflammatory actions in humans and animals.

BCC7374 SDZ WAG 994

BCC7032 PD 81723

BCC6124 KW 3902 Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment. Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP450). Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases. KW 3902

BCC5017 Valsartan Valsartan (CGP-48933) is an angiotensin II receptor antagonist for the treatment of high blood pressure and heart failure.

BCC6902 ZM 241385 ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM.

BCC7575 2-Chloroadenosine 2-Chloroadenosine, a stable adenosine analogue, protects against long term development of ischaemic cell loss in the rat hippocampus. 2-Chloroadenosine is an apparent competitive inhibitor of uridine influx (apparent Ki=33 μM) and high-affinity nitrobenzylthioinosine binding (apparent Ki=0.18 mM). 2-Chloroadenosine is a transported permeant for the nucleoside transporter in human erythrocytes.

BCC7640 8-(3-Chlorostyryl)caffeine

BCC7237 PSB 1115

BCC3798 Istradefylline (KW-6002) Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease.

BCC7306 SCH 58261 SCH 58261 is a potent, selective and competitive antagonist of adenosine A2A receptor with an IC50 of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively.

BCC6938 2-Cl-IB-MECA 2-Cl-IB-MECA is a selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively.

BCC6972 MRS 1220

BCC5753 MRS 1334

BCC7311 2'-MeCCPA

BCC7656 SLV 320 Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats. SLV 320

BCC6106 MRE 3008F20 MRE3008F20 is a highly potent and selective antagonist of adenosine A3 receptor (AA3R), inhibits agonist-induced cAMP elevation in resting T lymphocytes with an IC50 of 5 nM.

BCC7120 MRS 1706 MRS-1706 is a potent and selective adenosine A2B receptor inverse agonist. MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1 and A3 receptors respectively.

BCC7473 MRS 1754 MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats.

BCC5214 Nicergoline Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins.

BCC7030 VUF 5574

BCC6108 8-Aminoadenine Adenine receptor agonist

BCC6438 Regadenoson Regadenoson is an A2A adenosine receptor agonist that is a coronary vasodilator that is commonly used in pharmacologic stress testing.

BCC7372 SCH 442416

BCC6237 LUF 5834

BCC5804 NECA 5'-N-Ethylcarboxamidoadenosine (NECA) is a nonselective adenosine receptor agonist. NECA

BCC7161 2-Chloro-N6-cyclopentyladenosine Potent, selective A1 agonist

BCC1868 Preladenant Preladenant is a potent and competitive antagonist of the human adenosine A2A receptor with a Ki of 1.1 nM and has over 1000-fold selectivity over other adenosine receptors.

BCC7118 HEMADO HEMADO is a potent and selective adenosine A3 receptor agonist with a Ki of 1.1 nM at the human A3 subtype. HEMADO

BCC7160 N6-Cyclopentyladenosine N6-Cyclopentyladenosine (CPA) is a selective Adenosine A1 receptor agonist, with Ki values of 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively.

BCC7239 PSB 11 hydrochloride

BCC7240 PSB 36 PSB 36

BCC7163 CV 1808 CV 1808

BCC4973 Ticlopidine HCl Ticlopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC50 of ~2 μM.

BCC1845 Pentostatin Pentostatin (CI-825; Deoxycoformycin) is an irreversible inhibitor of adenosine deaminase with Ki of 2.5 pM.

BCC7238 PSB 10 hydrochloride

BCC5226 UK 14,304 Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

BCC7815 ANR 94 Adenosine A2A antagonist ANR 94

BCC6664 1,3-Dipropyl-8-phenylxanthine

BCC2011 Tozadenant Tozadenant is an adenosine A2A receptor antagonist, with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A.

BCC1710 LUF6000 LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR). LUF6000

BCC6197 BAY 60-6583 BAY 60-6583 is a potent and high-affinity agonist of adenosine A2B receptor (EC50 = 3 nM) over A1, A2A, and A3 receptors. BAY 60-6583 binds to mouse, rabbit, and dog A2BAR with Ki values of 750 nM, 340 nM and 330 nM, respectively. BAY 60-6583 has a cardioprotective effect in a myocardial ischemia model.

BCC7977 Lu AA 47070

BCC7890 XCC XCC

BCC7600 XAC XAC

Products for Adenosine Receptor