Intracellular Signaling

Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated more effectively and, theoretically, artificial tissues may be created.

Intracellular Signaling Products Targets

Products for Intracellular Signaling - Page 22

  1. Cat.No. Product Name Information/Activity
  2. BCN5524 Betulinic acid Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties. Betulinic acid acts as a new activator of NF-kB. Betulinic acid chemical structure
  3. BCC7075 AACOCF3 Phospholipase A<sub>2</sub> inhibitor AACOCF3 chemical structure
  4. BCC1509 D609 D609 is a selective competitive inhibitor of phosphatidyl choline-specific phospholipase C (PC-PLC), with Ki of 6.4 μM. D609 chemical structure
  5. BCC7537 Edelfosine 77286-66-9 Edelfosine chemical structure
  6. BCC7721 FIPI FIPI is a derivative of halopemide which potently inhibits both PLD1 and PLD2 with IC50s of 25 nM and 20 nM, respectively. FIPI chemical structure
  7. BCC7728 LY 311727 164083-84-5 LY 311727 chemical structure
  8. BCC2310 Varespladib (LY315920) Varespladib (LY315920) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively. Varespladib (LY315920) chemical structure
  9. BCC6716 OBAA 221632-26-4 OBAA chemical structure
  10. BCC7074 PACOCF3 Phospholipase A<sub>2</sub> inhibitor PACOCF3 chemical structure
  11. BCC5199 U-73122 U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50of 1-2.1 µM for PLC. U-73122 chemical structure

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