Intracellular Signaling

Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated more effectively and, theoretically, artificial tissues may be created.

Intracellular Signaling Products Targets

Products for Intracellular Signaling - Page 28

  1. Cat.No. Product Name Information/Activity
  2. BCC2412 Pifithrin-μ Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity. Pifithrin-μ chemical structure
  3. BCC2338 VER 155008 VER-155008 is an inhibitor of Hsp70, with IC50s of 0.5 μM, 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, and with a Kd of 0.3 μM for Hsp70. VER 155008 chemical structure
  4. BCC6241 MKT 077 MKT-077 is a rhodacyanine dye and also a heat shock protein 70 (Hsp70) inhibitor which exhibits significant antitumor activity. MKT 077 chemical structure
  5. BCC7968 TRC 051384 TRC051384 is a heat shock protein 70 (HSP70) inducer. TRC 051384 chemical structure
  6. BCC2121 17-AAG (KOS953) Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90. Tanespimycin (17-AAG) depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin (17-AAG) also downregulates the stk38 gene expression. 17-AAG (KOS953) chemical structure
  7. BCC2124 BIIB021 BIIB021 is an orally available, fully synthetic inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively. BIIB021 chemical structure
  8. BCC1175 17-DMAG (Alvespimycin) HCl Alvespimycin hydrochloride (17-DMAG hydrochloride; KOS-1022; BMS 826476) is a potent inhibitor of Hsp90, binding to Hsp90 with EC50 of 62±29 nM. 17-DMAG (Alvespimycin) HCl chemical structure
  9. BCC5600 EC 144 911397-80-3 EC 144 chemical structure
  10. BCC7676 Gedunin 2753-30-2 Gedunin chemical structure
  11. BCC2125 Geldanamycin Selective Hsp90 inhibitor; breast cancer stem cell inhibitor,Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin chemical structure

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